node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHAD | CNPY4 | ENSP00000258969 | ENSP00000262932 | Chondroadherin; Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | 0.612 |
CNPY1 | CNPY4 | ENSP00000317439 | ENSP00000262932 | Canopy FGF signaling regulator 1; Belongs to the canopy family. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | 0.584 |
CNPY2 | CNPY4 | ENSP00000273308 | ENSP00000262932 | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation; Belongs to the canopy family. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | 0.646 |
CNPY2 | HSP90B1 | ENSP00000273308 | ENSP00000299767 | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation; Belongs to the canopy family. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity). Belongs to the heat shock protein 90 family. | 0.431 |
CNPY4 | CHAD | ENSP00000262932 | ENSP00000258969 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Chondroadherin; Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily. | 0.612 |
CNPY4 | CNPY1 | ENSP00000262932 | ENSP00000317439 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Canopy FGF signaling regulator 1; Belongs to the canopy family. | 0.584 |
CNPY4 | CNPY2 | ENSP00000262932 | ENSP00000273308 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation; Belongs to the canopy family. | 0.646 |
CNPY4 | ERGIC3 | ENSP00000262932 | ENSP00000349970 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family. | 0.453 |
CNPY4 | GML | ENSP00000262932 | ENSP00000220940 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | 0.573 |
CNPY4 | HSP90B1 | ENSP00000262932 | ENSP00000299767 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity). Belongs to the heat shock protein 90 family. | 0.499 |
CNPY4 | LRIG3 | ENSP00000262932 | ENSP00000326759 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). | 0.457 |
CNPY4 | LY96 | ENSP00000262932 | ENSP00000284818 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Lymphocyte antigen 96; Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. | 0.828 |
CNPY4 | TLR2 | ENSP00000262932 | ENSP00000260010 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble [...] | 0.491 |
CNPY4 | TLR4 | ENSP00000262932 | ENSP00000363089 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non- conserved histidines and are, therefore, species-specific. Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression. In complex with [...] | 0.760 |
ERGIC3 | CNPY4 | ENSP00000349970 | ENSP00000262932 | Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | 0.453 |
GML | CNPY4 | ENSP00000220940 | ENSP00000262932 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | 0.573 |
GML | LRIG3 | ENSP00000220940 | ENSP00000326759 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). | 0.548 |
HSP90B1 | CNPY2 | ENSP00000299767 | ENSP00000273308 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity). Belongs to the heat shock protein 90 family. | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation; Belongs to the canopy family. | 0.431 |
HSP90B1 | CNPY4 | ENSP00000299767 | ENSP00000262932 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity). Belongs to the heat shock protein 90 family. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4. | 0.499 |
HSP90B1 | TLR2 | ENSP00000299767 | ENSP00000260010 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity). Belongs to the heat shock protein 90 family. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble [...] | 0.977 |