node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COG1 | COG2 | ENSP00000299886 | ENSP00000355629 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | 0.999 |
COG1 | COG3 | ENSP00000299886 | ENSP00000258654 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
COG1 | COG4 | ENSP00000299886 | ENSP00000315775 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Belongs to the COG4 family. | 0.999 |
COG1 | COG5 | ENSP00000299886 | ENSP00000297135 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family. | 0.999 |
COG1 | COG6 | ENSP00000299886 | ENSP00000397441 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | 0.999 |
COG1 | COG7 | ENSP00000299886 | ENSP00000305442 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function. | 0.999 |
COG1 | COG8 | ENSP00000299886 | ENSP00000497669 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
COG1 | COPB1 | ENSP00000299886 | ENSP00000249923 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also infl [...] | 0.672 |
COG1 | GOSR2 | ENSP00000299886 | ENSP00000461784 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network; Belongs to the GOSR2 family. | 0.866 |
COG1 | VPS52 | ENSP00000299886 | ENSP00000409952 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized tr [...] | 0.814 |
COG2 | COG1 | ENSP00000355629 | ENSP00000299886 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | 0.999 |
COG2 | COG3 | ENSP00000355629 | ENSP00000258654 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
COG2 | COG4 | ENSP00000355629 | ENSP00000315775 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Belongs to the COG4 family. | 0.999 |
COG2 | COG5 | ENSP00000355629 | ENSP00000297135 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family. | 0.999 |
COG2 | COG6 | ENSP00000355629 | ENSP00000397441 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | 0.999 |
COG2 | COG7 | ENSP00000355629 | ENSP00000305442 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function. | 0.999 |
COG2 | COG8 | ENSP00000355629 | ENSP00000497669 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
COG2 | COPB1 | ENSP00000355629 | ENSP00000249923 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also infl [...] | 0.833 |
COG2 | GOSR2 | ENSP00000355629 | ENSP00000461784 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network; Belongs to the GOSR2 family. | 0.843 |
COG2 | VPS52 | ENSP00000355629 | ENSP00000409952 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized tr [...] | 0.801 |