node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRCT1 | CRNN | ENSP00000357779 | ENSP00000271835 | Cysteine rich C-terminal 1. | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | 0.749 |
CRCT1 | KRT78 | ENSP00000357779 | ENSP00000306261 | Cysteine rich C-terminal 1. | Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family. | 0.444 |
CRCT1 | KRTDAP | ENSP00000357779 | ENSP00000339251 | Cysteine rich C-terminal 1. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.638 |
CRCT1 | SPINK7 | ENSP00000357779 | ENSP00000274565 | Cysteine rich C-terminal 1. | Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor. | 0.428 |
CRCT1 | SPRR3 | ENSP00000357779 | ENSP00000330391 | Cysteine rich C-terminal 1. | Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes. | 0.694 |
CRNN | CRCT1 | ENSP00000271835 | ENSP00000357779 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Cysteine rich C-terminal 1. | 0.749 |
CRNN | DEPP1 | ENSP00000271835 | ENSP00000298295 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS. | 0.952 |
CRNN | KRT4 | ENSP00000271835 | ENSP00000448220 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | 0.704 |
CRNN | KRT78 | ENSP00000271835 | ENSP00000306261 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family. | 0.758 |
CRNN | KRTDAP | ENSP00000271835 | ENSP00000339251 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.605 |
CRNN | SPINK5 | ENSP00000271835 | ENSP00000352936 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti- inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation- involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. | 0.675 |
CRNN | SPINK7 | ENSP00000271835 | ENSP00000274565 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor. | 0.696 |
CRNN | SPRR3 | ENSP00000271835 | ENSP00000330391 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes. | 0.722 |
CRNN | TGM3 | ENSP00000271835 | ENSP00000370867 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cros [...] | 0.736 |
CRNN | TMPRSS11B | ENSP00000271835 | ENSP00000330475 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Transmembrane protease serine 11B; Serine protease. | 0.863 |
DEPP1 | CRNN | ENSP00000298295 | ENSP00000271835 | Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS. | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | 0.952 |
KRT4 | CRNN | ENSP00000448220 | ENSP00000271835 | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | 0.704 |
KRT4 | KRT78 | ENSP00000448220 | ENSP00000306261 | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family. | 0.563 |
KRT4 | KRTDAP | ENSP00000448220 | ENSP00000339251 | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.545 |
KRT4 | SPINK5 | ENSP00000448220 | ENSP00000352936 | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti- inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation- involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. | 0.427 |