node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANXA13 | CSMD3 | ENSP00000262219 | ENSP00000297405 | Annexin A13; [Isoform A]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup. | CUB and sushi domain-containing protein 3; Involved in dendrite development. | 0.837 |
ANXA13 | EXT1 | ENSP00000262219 | ENSP00000367446 | Annexin A13; [Isoform A]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup. | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | 0.747 |
ANXA13 | TRPS1 | ENSP00000262219 | ENSP00000379065 | Annexin A13; [Isoform A]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup. | Zinc finger transcription factor Trps1; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. | 0.727 |
CSMD3 | ANXA13 | ENSP00000297405 | ENSP00000262219 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Annexin A13; [Isoform A]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup. | 0.837 |
CSMD3 | EXT1 | ENSP00000297405 | ENSP00000367446 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | 0.710 |
CSMD3 | FAT3 | ENSP00000297405 | ENSP00000432586 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | 0.678 |
CSMD3 | LRP1B | ENSP00000297405 | ENSP00000374135 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. | 0.779 |
CSMD3 | MUC16 | ENSP00000297405 | ENSP00000381008 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Mucin-16; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. | 0.721 |
CSMD3 | PCLO | ENSP00000297405 | ENSP00000334319 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Protein piccolo; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). O [...] | 0.670 |
CSMD3 | SYNE1 | ENSP00000297405 | ENSP00000356224 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus- centrosome attachment and nuclear migrati [...] | 0.674 |
CSMD3 | TRPS1 | ENSP00000297405 | ENSP00000379065 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Zinc finger transcription factor Trps1; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. | 0.854 |
CSMD3 | TTN | ENSP00000297405 | ENSP00000467141 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase; Belongs to the protein kinase su [...] | 0.724 |
CSMD3 | ZFHX4 | ENSP00000297405 | ENSP00000498627 | CUB and sushi domain-containing protein 3; Involved in dendrite development. | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. | 0.664 |
EXT1 | ANXA13 | ENSP00000367446 | ENSP00000262219 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | Annexin A13; [Isoform A]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup. | 0.747 |
EXT1 | CSMD3 | ENSP00000367446 | ENSP00000297405 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | CUB and sushi domain-containing protein 3; Involved in dendrite development. | 0.710 |
EXT1 | TRPS1 | ENSP00000367446 | ENSP00000379065 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | Zinc finger transcription factor Trps1; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. | 0.931 |
FAT3 | CSMD3 | ENSP00000432586 | ENSP00000297405 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | CUB and sushi domain-containing protein 3; Involved in dendrite development. | 0.678 |
FAT3 | MUC16 | ENSP00000432586 | ENSP00000381008 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Mucin-16; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. | 0.547 |
FAT3 | PCLO | ENSP00000432586 | ENSP00000334319 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Protein piccolo; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). O [...] | 0.531 |
FAT3 | SYNE1 | ENSP00000432586 | ENSP00000356224 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus- centrosome attachment and nuclear migrati [...] | 0.474 |