node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN7L2 | CYB561D1 | ENSP00000358886 | ENSP00000358884 | Ataxin-7-like protein 2; Ataxin 7 like 2. | Cytochrome b561 family member D1. | 0.428 |
BCCIP | CYB561D1 | ENSP00000357748 | ENSP00000358884 | BRCA2 and CDKN1A-interacting protein; During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in [...] | Cytochrome b561 family member D1. | 0.454 |
CCDC9 | CYB561D1 | ENSP00000221922 | ENSP00000358884 | Coiled-coil domain containing 9. | Cytochrome b561 family member D1. | 0.414 |
CYB561D1 | ATXN7L2 | ENSP00000358884 | ENSP00000358886 | Cytochrome b561 family member D1. | Ataxin-7-like protein 2; Ataxin 7 like 2. | 0.428 |
CYB561D1 | BCCIP | ENSP00000358884 | ENSP00000357748 | Cytochrome b561 family member D1. | BRCA2 and CDKN1A-interacting protein; During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in [...] | 0.454 |
CYB561D1 | CCDC9 | ENSP00000358884 | ENSP00000221922 | Cytochrome b561 family member D1. | Coiled-coil domain containing 9. | 0.414 |
CYB561D1 | EFNA4 | ENSP00000358884 | ENSP00000414378 | Cytochrome b561 family member D1. | Ephrin-A4; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. | 0.401 |
CYB561D1 | GTF2A2 | ENSP00000358884 | ENSP00000379372 | Cytochrome b561 family member D1. | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. | 0.499 |
CYB561D1 | KCTD21 | ENSP00000358884 | ENSP00000339340 | Cytochrome b561 family member D1. | BTB/POZ domain-containing protein KCTD21; Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). | 0.729 |
CYB561D1 | POLR3K | ENSP00000358884 | ENSP00000293860 | Cytochrome b561 family member D1. | DNA-directed RNA polymerase III subunit RPC10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non- self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus- [...] | 0.468 |
CYB561D1 | SNX22 | ENSP00000358884 | ENSP00000323435 | Cytochrome b561 family member D1. | Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the sorting nexin family. | 0.498 |
CYB561D1 | SUOX | ENSP00000358884 | ENSP00000377668 | Cytochrome b561 family member D1. | Sulfite oxidase, mitochondrial; Sulfite oxidase. | 0.410 |
CYB561D1 | ZNF701 | ENSP00000358884 | ENSP00000444339 | Cytochrome b561 family member D1. | Zinc finger protein 701; May be involved in transcriptional regulation. | 0.422 |
EFNA4 | CYB561D1 | ENSP00000414378 | ENSP00000358884 | Ephrin-A4; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. | Cytochrome b561 family member D1. | 0.401 |
GTF2A2 | CYB561D1 | ENSP00000379372 | ENSP00000358884 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. | Cytochrome b561 family member D1. | 0.499 |
GTF2A2 | POLR3K | ENSP00000379372 | ENSP00000293860 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. | DNA-directed RNA polymerase III subunit RPC10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non- self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus- [...] | 0.619 |
KCTD21 | CYB561D1 | ENSP00000339340 | ENSP00000358884 | BTB/POZ domain-containing protein KCTD21; Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). | Cytochrome b561 family member D1. | 0.729 |
POLR3K | CYB561D1 | ENSP00000293860 | ENSP00000358884 | DNA-directed RNA polymerase III subunit RPC10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non- self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus- [...] | Cytochrome b561 family member D1. | 0.468 |
POLR3K | GTF2A2 | ENSP00000293860 | ENSP00000379372 | DNA-directed RNA polymerase III subunit RPC10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non- self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus- [...] | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. | 0.619 |
SNX22 | CYB561D1 | ENSP00000323435 | ENSP00000358884 | Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the sorting nexin family. | Cytochrome b561 family member D1. | 0.498 |