node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOOL | BRWD3 | ENSP00000362268 | ENSP00000362372 | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. | 0.465 |
APOOL | CPXCR1 | ENSP00000362268 | ENSP00000276127 | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | CPX chromosome region candidate 1. | 0.418 |
APOOL | CYLC1 | ENSP00000362268 | ENSP00000331556 | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. | 0.579 |
APOOL | RPS6KA6 | ENSP00000362268 | ENSP00000262752 | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. | 0.555 |
APOOL | SATL1 | ENSP00000362268 | ENSP00000425421 | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | Spermidine/spermine N1-acetyl transferase like 1. | 0.613 |
APOOL | TENT5D | ENSP00000362268 | ENSP00000443410 | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | Terminal nucleotidyltransferase 5D; Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase; Belongs to the TENT family. | 0.416 |
BRWD3 | APOOL | ENSP00000362372 | ENSP00000362268 | Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | 0.465 |
BRWD3 | CYLC1 | ENSP00000362372 | ENSP00000331556 | Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. | 0.525 |
BRWD3 | RPS6KA6 | ENSP00000362372 | ENSP00000262752 | Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. | 0.422 |
BRWD3 | SATL1 | ENSP00000362372 | ENSP00000425421 | Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. | Spermidine/spermine N1-acetyl transferase like 1. | 0.421 |
BRWD3 | TENT5D | ENSP00000362372 | ENSP00000443410 | Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. | Terminal nucleotidyltransferase 5D; Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase; Belongs to the TENT family. | 0.483 |
CCIN | CYLC1 | ENSP00000334996 | ENSP00000331556 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. | 0.982 |
CCIN | CYLC2 | ENSP00000334996 | ENSP00000420256 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Cylicin-2; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. | 0.989 |
CCNL1 | CYLC1 | ENSP00000295926 | ENSP00000331556 | Cyclin-L1; Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto- oncogene in head and neck squamous cell carcinomas (HNSCC). | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. | 0.578 |
CPXCR1 | APOOL | ENSP00000276127 | ENSP00000362268 | CPX chromosome region candidate 1. | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | 0.418 |
CPXCR1 | CYLC1 | ENSP00000276127 | ENSP00000331556 | CPX chromosome region candidate 1. | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. | 0.652 |
CPXCR1 | SATL1 | ENSP00000276127 | ENSP00000425421 | CPX chromosome region candidate 1. | Spermidine/spermine N1-acetyl transferase like 1. | 0.583 |
CYLC1 | APOOL | ENSP00000331556 | ENSP00000362268 | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | 0.579 |
CYLC1 | BRWD3 | ENSP00000331556 | ENSP00000362372 | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. | Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. | 0.525 |
CYLC1 | CCIN | ENSP00000331556 | ENSP00000334996 | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | 0.982 |