node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CKAP4 | CYSTM1 | ENSP00000367265 | ENSP00000261811 | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF. | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | 0.440 |
CKAP4 | TMX1 | ENSP00000367265 | ENSP00000393316 | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF. | Thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. | 0.412 |
CLEC5A | CYSTM1 | ENSP00000449999 | ENSP00000261811 | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP. Regulates inflammatory responses (By similarity). | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | 0.427 |
CLEC5A | PTAFR | ENSP00000449999 | ENSP00000442658 | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP. Regulates inflammatory responses (By similarity). | Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. | 0.509 |
CYSTM1 | CKAP4 | ENSP00000261811 | ENSP00000367265 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF. | 0.440 |
CYSTM1 | CLEC5A | ENSP00000261811 | ENSP00000449999 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP. Regulates inflammatory responses (By similarity). | 0.427 |
CYSTM1 | PTAFR | ENSP00000261811 | ENSP00000442658 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. | 0.410 |
CYSTM1 | TMX1 | ENSP00000261811 | ENSP00000393316 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | Thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. | 0.574 |
CYSTM1 | UQCR10 | ENSP00000261811 | ENSP00000332887 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | Cytochrome b-c1 complex subunit 9; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] | 0.573 |
CYSTM1 | ZBTB18 | ENSP00000261811 | ENSP00000351539 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May [...] | 0.425 |
CYSTM1 | ZNF613 | ENSP00000261811 | ENSP00000293471 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | Zinc finger protein 613; May be involved in transcriptional regulation. | 0.462 |
PTAFR | CLEC5A | ENSP00000442658 | ENSP00000449999 | Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP. Regulates inflammatory responses (By similarity). | 0.509 |
PTAFR | CYSTM1 | ENSP00000442658 | ENSP00000261811 | Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | 0.410 |
PTAFR | ZBTB18 | ENSP00000442658 | ENSP00000351539 | Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. | Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May [...] | 0.424 |
TMX1 | CKAP4 | ENSP00000393316 | ENSP00000367265 | Thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF. | 0.412 |
TMX1 | CYSTM1 | ENSP00000393316 | ENSP00000261811 | Thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | 0.574 |
UQCR10 | CYSTM1 | ENSP00000332887 | ENSP00000261811 | Cytochrome b-c1 complex subunit 9; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | 0.573 |
ZBTB18 | CYSTM1 | ENSP00000351539 | ENSP00000261811 | Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May [...] | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | 0.425 |
ZBTB18 | PTAFR | ENSP00000351539 | ENSP00000442658 | Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May [...] | Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. | 0.424 |
ZNF613 | CYSTM1 | ENSP00000293471 | ENSP00000261811 | Zinc finger protein 613; May be involved in transcriptional regulation. | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1. | 0.462 |