node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DEFB103A | DEFB110 | ENSP00000320951 | ENSP00000360190 | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. | Beta-defensin 110; Has antibacterial activity. | 0.724 |
DEFB103A | DEFB114 | ENSP00000320951 | ENSP00000312702 | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | 0.777 |
DEFB103A | DEFB118 | ENSP00000320951 | ENSP00000253381 | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. | Beta-defensin 118; Has antibacterial activity. | 0.685 |
DEFB103A | DEFB124 | ENSP00000320951 | ENSP00000326309 | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. | Beta-defensin 124; Has antibacterial activity; Belongs to the beta-defensin family. | 0.576 |
DEFB103A | DEFB125 | ENSP00000320951 | ENSP00000371847 | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. | Beta-defensin 125; Has antibacterial activity; Belongs to the beta-defensin family. | 0.499 |
DEFB103A | DEFB126 | ENSP00000320951 | ENSP00000371835 | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. | Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...] | 0.696 |
DEFB103A | DEFB127 | ENSP00000320951 | ENSP00000371825 | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. | Beta-defensin 127; Has antibacterial activity. | 0.637 |
DEFB103A | DEFB128 | ENSP00000320951 | ENSP00000335382 | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. | Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family. | 0.699 |
DEFB103A | DEFB134 | ENSP00000320951 | ENSP00000435010 | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. | Beta-defensin 134; Has antibacterial activity; Belongs to the beta-defensin family. | 0.583 |
DEFB103A | DEFB135 | ENSP00000320951 | ENSP00000371643 | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. | Beta-defensin 135; Has antibacterial activity; Belongs to the beta-defensin family. | 0.549 |
DEFB110 | DEFB103A | ENSP00000360190 | ENSP00000320951 | Beta-defensin 110; Has antibacterial activity. | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. | 0.724 |
DEFB110 | DEFB114 | ENSP00000360190 | ENSP00000312702 | Beta-defensin 110; Has antibacterial activity. | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | 0.799 |
DEFB110 | DEFB118 | ENSP00000360190 | ENSP00000253381 | Beta-defensin 110; Has antibacterial activity. | Beta-defensin 118; Has antibacterial activity. | 0.753 |
DEFB110 | DEFB124 | ENSP00000360190 | ENSP00000326309 | Beta-defensin 110; Has antibacterial activity. | Beta-defensin 124; Has antibacterial activity; Belongs to the beta-defensin family. | 0.660 |
DEFB110 | DEFB125 | ENSP00000360190 | ENSP00000371847 | Beta-defensin 110; Has antibacterial activity. | Beta-defensin 125; Has antibacterial activity; Belongs to the beta-defensin family. | 0.674 |
DEFB110 | DEFB126 | ENSP00000360190 | ENSP00000371835 | Beta-defensin 110; Has antibacterial activity. | Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...] | 0.753 |
DEFB110 | DEFB127 | ENSP00000360190 | ENSP00000371825 | Beta-defensin 110; Has antibacterial activity. | Beta-defensin 127; Has antibacterial activity. | 0.834 |
DEFB110 | DEFB128 | ENSP00000360190 | ENSP00000335382 | Beta-defensin 110; Has antibacterial activity. | Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family. | 0.766 |
DEFB110 | DEFB134 | ENSP00000360190 | ENSP00000435010 | Beta-defensin 110; Has antibacterial activity. | Beta-defensin 134; Has antibacterial activity; Belongs to the beta-defensin family. | 0.751 |
DEFB110 | DEFB135 | ENSP00000360190 | ENSP00000371643 | Beta-defensin 110; Has antibacterial activity. | Beta-defensin 135; Has antibacterial activity; Belongs to the beta-defensin family. | 0.601 |