node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C15orf40 | C8orf82 | ENSP00000403987 | ENSP00000436621 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | 0.579 |
C15orf40 | DGLUCY | ENSP00000403987 | ENSP00000428263 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | 0.448 |
C8orf82 | C15orf40 | ENSP00000436621 | ENSP00000403987 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | 0.579 |
C8orf82 | DGLUCY | ENSP00000436621 | ENSP00000428263 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | 0.451 |
DGLUCY | C15orf40 | ENSP00000428263 | ENSP00000403987 | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | 0.448 |
DGLUCY | C8orf82 | ENSP00000428263 | ENSP00000436621 | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | 0.451 |
DGLUCY | EPB42 | ENSP00000428263 | ENSP00000497777 | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. | 0.467 |
DGLUCY | GLS | ENSP00000428263 | ENSP00000317379 | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain ; Belongs to the glutaminase family. | 0.900 |
DGLUCY | GLS2 | ENSP00000428263 | ENSP00000310447 | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. | 0.900 |
DGLUCY | IRAK2 | ENSP00000428263 | ENSP00000256458 | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.427 |
DGLUCY | MKNK2 | ENSP00000428263 | ENSP00000250896 | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | MAP kinase-interacting serine/threonine-protein kinase 2; Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A- inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a [...] | 0.441 |
DGLUCY | NIPSNAP3B | ENSP00000428263 | ENSP00000363894 | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | Nipsnap homolog 3B; Belongs to the NipSnap family. | 0.436 |
DGLUCY | NSFL1C | ENSP00000428263 | ENSP00000418529 | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | NSFL1 cofactor p47; Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP- mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis ; Belongs to [...] | 0.504 |
DGLUCY | STARD4 | ENSP00000428263 | ENSP00000296632 | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | StAR-related lipid transfer protein 4; Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols. | 0.469 |
EPB42 | DGLUCY | ENSP00000497777 | ENSP00000428263 | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | 0.467 |
GLS | DGLUCY | ENSP00000317379 | ENSP00000428263 | Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain ; Belongs to the glutaminase family. | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | 0.900 |
GLS | GLS2 | ENSP00000317379 | ENSP00000310447 | Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain ; Belongs to the glutaminase family. | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. | 0.916 |
GLS2 | DGLUCY | ENSP00000310447 | ENSP00000428263 | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | 0.900 |
GLS2 | GLS | ENSP00000310447 | ENSP00000317379 | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. | Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain ; Belongs to the glutaminase family. | 0.916 |
IRAK2 | DGLUCY | ENSP00000256458 | ENSP00000428263 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline. | 0.427 |