node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAG6 | DMKN | ENSP00000365131 | ENSP00000342012 | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail- anchored/type II transmembrane proteins to the end [...] | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | 0.547 |
CDSN | CNFN | ENSP00000365465 | ENSP00000222032 | Corneodesmosin; Important for the epidermal barrier integrity. | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | 0.422 |
CDSN | DMKN | ENSP00000365465 | ENSP00000342012 | Corneodesmosin; Important for the epidermal barrier integrity. | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | 0.477 |
CDSN | KRT1 | ENSP00000365465 | ENSP00000252244 | Corneodesmosin; Important for the epidermal barrier integrity. | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. | 0.699 |
CDSN | KRTDAP | ENSP00000365465 | ENSP00000339251 | Corneodesmosin; Important for the epidermal barrier integrity. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.665 |
CDSN | SBSN | ENSP00000365465 | ENSP00000430242 | Corneodesmosin; Important for the epidermal barrier integrity. | Suprabasin. | 0.452 |
CNFN | CDSN | ENSP00000222032 | ENSP00000365465 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.422 |
CNFN | DMKN | ENSP00000222032 | ENSP00000342012 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | 0.432 |
CNFN | KRTDAP | ENSP00000222032 | ENSP00000339251 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.805 |
CNFN | SBSN | ENSP00000222032 | ENSP00000430242 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | Suprabasin. | 0.606 |
DMKN | BAG6 | ENSP00000342012 | ENSP00000365131 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail- anchored/type II transmembrane proteins to the end [...] | 0.547 |
DMKN | CDSN | ENSP00000342012 | ENSP00000365465 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.477 |
DMKN | CNFN | ENSP00000342012 | ENSP00000222032 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. | 0.432 |
DMKN | KLK8 | ENSP00000342012 | ENSP00000375682 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...] | 0.424 |
DMKN | KRT1 | ENSP00000342012 | ENSP00000252244 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. | 0.435 |
DMKN | KRT5 | ENSP00000342012 | ENSP00000252242 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Keratin, type II cytoskeletal 5; Keratin 5; Belongs to the intermediate filament family. | 0.504 |
DMKN | KRTDAP | ENSP00000342012 | ENSP00000339251 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.733 |
DMKN | MYH14 | ENSP00000342012 | ENSP00000493594 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. | 0.431 |
DMKN | RBM24 | ENSP00000342012 | ENSP00000368341 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | RNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). I [...] | 0.420 |
DMKN | SBSN | ENSP00000342012 | ENSP00000430242 | Dermokine; May act as a soluble regulator of keratinocyte differentiation. | Suprabasin. | 0.760 |