DNAJC12 protein (human) - STRING interaction network

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Score

DNAJC12

DnaJ heat shock protein family member C12. (198 aa)

Predicted Functional Partners:

DNAJB4

0.843

DNAJB1

0.781

HSPA4

0.770

TPH1

0.668

TPH2

0.654

PAH

0.603

DNAJC6

0.581

HSPA8

0.578

ERI2

0.566

GCHFR

0.558

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNAJB1	DNAJB4	ENSP00000254322	ENSP00000359799	DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	0.866
DNAJB1	DNAJC12	ENSP00000254322	ENSP00000225171	DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	DnaJ heat shock protein family member C12.	0.781
DNAJB1	DNAJC6	ENSP00000254322	ENSP00000360108	DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin- mediated endocytosis in neurons (By similarity).	0.786
DNAJB1	HSPA4	ENSP00000254322	ENSP00000302961	DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	0.999
DNAJB1	HSPA8	ENSP00000254322	ENSP00000437125	DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	0.999
DNAJB4	DNAJB1	ENSP00000359799	ENSP00000254322	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	0.866
DNAJB4	DNAJC12	ENSP00000359799	ENSP00000225171	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	DnaJ heat shock protein family member C12.	0.843
DNAJB4	DNAJC6	ENSP00000359799	ENSP00000360108	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin- mediated endocytosis in neurons (By similarity).	0.807
DNAJB4	HSPA4	ENSP00000359799	ENSP00000302961	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	0.982
DNAJB4	HSPA8	ENSP00000359799	ENSP00000437125	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	0.967
DNAJC12	DNAJB1	ENSP00000225171	ENSP00000254322	DnaJ heat shock protein family member C12.	DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	0.781
DNAJC12	DNAJB4	ENSP00000225171	ENSP00000359799	DnaJ heat shock protein family member C12.	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	0.843
DNAJC12	DNAJC6	ENSP00000225171	ENSP00000360108	DnaJ heat shock protein family member C12.	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin- mediated endocytosis in neurons (By similarity).	0.581
DNAJC12	ERI2	ENSP00000225171	ENSP00000350651	DnaJ heat shock protein family member C12.	ERI1 exoribonuclease family member 2; Belongs to the ERI2 family.	0.566
DNAJC12	GCHFR	ENSP00000225171	ENSP00000260447	DnaJ heat shock protein family member C12.	GTP cyclohydrolase 1 feedback regulatory protein; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.	0.558
DNAJC12	HSPA4	ENSP00000225171	ENSP00000302961	DnaJ heat shock protein family member C12.	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	0.770
DNAJC12	HSPA8	ENSP00000225171	ENSP00000437125	DnaJ heat shock protein family member C12.	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	0.578
DNAJC12	PAH	ENSP00000225171	ENSP00000448059	DnaJ heat shock protein family member C12.	Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	0.603
DNAJC12	TPH1	ENSP00000225171	ENSP00000250018	DnaJ heat shock protein family member C12.	Tryptophan hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	0.668
DNAJC12	TPH2	ENSP00000225171	ENSP00000329093	DnaJ heat shock protein family member C12.	Tryptophan hydroxylase 2.	0.654