node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRIX1 | DDX28 | ENSP00000338862 | ENSP00000332340 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Probable ATP-dependent RNA helicase DDX28; Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)- dependent ATPase activity. | 0.756 |
BRIX1 | DUS1L | ENSP00000338862 | ENSP00000303515 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus1 subfamily. | 0.407 |
BRIX1 | DUS2 | ENSP00000338862 | ENSP00000455229 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. | 0.658 |
BRIX1 | EPRS1 | ENSP00000338862 | ENSP00000355890 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Bifunctional glutamate/proline--tRNA ligase; Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it [...] | 0.446 |
BRIX1 | PUS3 | ENSP00000338862 | ENSP00000227474 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | tRNA pseudouridine(38/39) synthase; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. | 0.587 |
BRIX1 | THUMPD1 | ENSP00000338862 | ENSP00000379392 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | THUMP domain-containing protein 1; Functions as a tRNA-binding adapter to mediate NAT10- dependent tRNA acetylation. | 0.415 |
BRIX1 | TRMT1 | ENSP00000338862 | ENSP00000466967 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. | 0.583 |
BRIX1 | TRMT5 | ENSP00000338862 | ENSP00000261249 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. | 0.413 |
BRIX1 | TRUB1 | ENSP00000338862 | ENSP00000298746 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Probable tRNA pseudouridine synthase 1; Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs ; Belongs to the pseudouridine synthase TruB family. | 0.700 |
DDX28 | BRIX1 | ENSP00000332340 | ENSP00000338862 | Probable ATP-dependent RNA helicase DDX28; Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)- dependent ATPase activity. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | 0.756 |
DDX28 | DUS2 | ENSP00000332340 | ENSP00000455229 | Probable ATP-dependent RNA helicase DDX28; Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)- dependent ATPase activity. | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. | 0.677 |
DDX28 | TRUB1 | ENSP00000332340 | ENSP00000298746 | Probable ATP-dependent RNA helicase DDX28; Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)- dependent ATPase activity. | Probable tRNA pseudouridine synthase 1; Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs ; Belongs to the pseudouridine synthase TruB family. | 0.440 |
DUS1L | BRIX1 | ENSP00000303515 | ENSP00000338862 | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus1 subfamily. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | 0.407 |
DUS1L | DUS2 | ENSP00000303515 | ENSP00000455229 | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus1 subfamily. | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. | 0.618 |
DUS1L | PUS3 | ENSP00000303515 | ENSP00000227474 | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus1 subfamily. | tRNA pseudouridine(38/39) synthase; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. | 0.616 |
DUS1L | THUMPD1 | ENSP00000303515 | ENSP00000379392 | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus1 subfamily. | THUMP domain-containing protein 1; Functions as a tRNA-binding adapter to mediate NAT10- dependent tRNA acetylation. | 0.469 |
DUS1L | TRIT1 | ENSP00000303515 | ENSP00000321810 | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus1 subfamily. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). | 0.406 |
DUS1L | TRMT1 | ENSP00000303515 | ENSP00000466967 | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus1 subfamily. | tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. | 0.617 |
DUS1L | TRMT5 | ENSP00000303515 | ENSP00000261249 | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus1 subfamily. | tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. | 0.549 |
DUS2 | BRIX1 | ENSP00000455229 | ENSP00000338862 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | 0.658 |