node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COX4I2 | DUSP15 | ENSP00000365243 | ENSP00000278979 | Cytochrome c oxidase subunit 4 isoform 2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives tran [...] | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.421 |
DUSP15 | COX4I2 | ENSP00000278979 | ENSP00000365243 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Cytochrome c oxidase subunit 4 isoform 2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives tran [...] | 0.421 |
DUSP15 | DUSP22 | ENSP00000278979 | ENSP00000397459 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Dual specificity protein phosphatase 22; Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity). | 0.425 |
DUSP15 | DUSP23 | ENSP00000278979 | ENSP00000357087 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Dual specificity protein phosphatase 23; Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.729 |
DUSP15 | FOXS1 | ENSP00000278979 | ENSP00000365145 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Forkhead box protein S1; Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity). | 0.420 |
DUSP15 | MYRF | ENSP00000278979 | ENSP00000278836 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | 0.542 |
DUSP15 | PDCD11 | ENSP00000278979 | ENSP00000358812 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Protein RRP5 homolog; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. | 0.452 |
DUSP15 | PPP1R32 | ENSP00000278979 | ENSP00000344140 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Protein phosphatase 1 regulatory subunit 32. | 0.429 |
DUSP15 | PTPN1 | ENSP00000278979 | ENSP00000360683 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c- src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. Belongs to the protein-tyrosi [...] | 0.416 |
DUSP15 | UBE2QL1 | ENSP00000278979 | ENSP00000382713 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Ubiquitin-conjugating enzyme E2Q-like protein 1; Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7; Belongs to the ubiquitin-conjugating enzyme family. | 0.451 |
DUSP15 | ZNF215 | ENSP00000278979 | ENSP00000278319 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Zinc finger protein 215; May be involved in transcriptional regulation. | 0.463 |
DUSP22 | DUSP15 | ENSP00000397459 | ENSP00000278979 | Dual specificity protein phosphatase 22; Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity). | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.425 |
DUSP22 | DUSP23 | ENSP00000397459 | ENSP00000357087 | Dual specificity protein phosphatase 22; Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity). | Dual specificity protein phosphatase 23; Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.603 |
DUSP23 | DUSP15 | ENSP00000357087 | ENSP00000278979 | Dual specificity protein phosphatase 23; Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.729 |
DUSP23 | DUSP22 | ENSP00000357087 | ENSP00000397459 | Dual specificity protein phosphatase 23; Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Dual specificity protein phosphatase 22; Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity). | 0.603 |
DUSP23 | PTPN1 | ENSP00000357087 | ENSP00000360683 | Dual specificity protein phosphatase 23; Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c- src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. Belongs to the protein-tyrosi [...] | 0.433 |
FOXS1 | DUSP15 | ENSP00000365145 | ENSP00000278979 | Forkhead box protein S1; Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity). | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.420 |
MYRF | DUSP15 | ENSP00000278836 | ENSP00000278979 | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.542 |
MYRF | PPP1R32 | ENSP00000278836 | ENSP00000344140 | Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifi [...] | Protein phosphatase 1 regulatory subunit 32. | 0.434 |
PDCD11 | DUSP15 | ENSP00000358812 | ENSP00000278979 | Protein RRP5 homolog; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.452 |