node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRIX1 | EBNA1BP2 | ENSP00000338862 | ENSP00000407323 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | 0.999 |
BRIX1 | FTSJ3 | ENSP00000338862 | ENSP00000396673 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. | 0.970 |
BRIX1 | MAK16 | ENSP00000338862 | ENSP00000353246 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | MAK16 homolog. | 0.997 |
BRIX1 | MRTO4 | ENSP00000338862 | ENSP00000364320 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. | 0.997 |
BRIX1 | NIFK | ENSP00000338862 | ENSP00000285814 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Nucleolar protein interacting with the FHA domain of MKI67. | 0.999 |
BRIX1 | NIP7 | ENSP00000338862 | ENSP00000254940 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | 60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. | 0.999 |
BRIX1 | NOC2L | ENSP00000338862 | ENSP00000317992 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. | 0.996 |
BRIX1 | PES1 | ENSP00000338862 | ENSP00000346725 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Belongs to the pescadillo family. | 0.993 |
BRIX1 | RPF2 | ENSP00000338862 | ENSP00000402338 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | 0.993 |
BRIX1 | WDR12 | ENSP00000338862 | ENSP00000261015 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | 0.998 |
EBNA1BP2 | BRIX1 | ENSP00000407323 | ENSP00000338862 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | 0.999 |
EBNA1BP2 | FTSJ3 | ENSP00000407323 | ENSP00000396673 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. | 0.999 |
EBNA1BP2 | MAK16 | ENSP00000407323 | ENSP00000353246 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | MAK16 homolog. | 0.999 |
EBNA1BP2 | MRTO4 | ENSP00000407323 | ENSP00000364320 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. | 0.998 |
EBNA1BP2 | NIFK | ENSP00000407323 | ENSP00000285814 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Nucleolar protein interacting with the FHA domain of MKI67. | 0.999 |
EBNA1BP2 | NIP7 | ENSP00000407323 | ENSP00000254940 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | 60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. | 0.999 |
EBNA1BP2 | NOC2L | ENSP00000407323 | ENSP00000317992 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. | 0.998 |
EBNA1BP2 | PES1 | ENSP00000407323 | ENSP00000346725 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Belongs to the pescadillo family. | 0.999 |
EBNA1BP2 | RPF2 | ENSP00000407323 | ENSP00000402338 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | 0.999 |
EBNA1BP2 | WDR12 | ENSP00000407323 | ENSP00000261015 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | 0.998 |