STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EFCAB5EF-hand calcium-binding domain-containing protein 5; EF-hand calcium binding domain 5. (1503 aa)    
Predicted Functional Partners:
NSRP1
Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
 
    
 0.725
NPHP3-ACAD11
NPHP3-ACAD11 readthrough.
    
 
 0.546
CCDC116
Coiled-coil domain containing 116.
   
  
 0.511
TOR2A
Torsin-2A; Torsin family 2 member A; Belongs to the ClpA/ClpB family. Torsin subfamily.
      
 0.456
ERICH6
Glutamate-rich protein 6; Glutamate rich 6.
   
  
 0.449
C6orf226
Uncharacterized protein C6orf226; Chromosome 6 open reading frame 226.
      
 0.447
CCDC105
Coiled-coil domain containing 105.
   
 
 0.438
WDR90
WD repeat-containing protein 90; Required for efficient primary cilium formation.
    
 
 0.438
OPRM1
Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]
   
    0.426
TCF23
Transcription factor 23; Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).
   
  
 0.423
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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