node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPGM | ENO4 | ENSP00000376840 | ENSP00000345555 | Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. | Enolase 4; May be required for sperm motility and function. | 0.960 |
BPGM | GLYCTK | ENSP00000376840 | ENSP00000389175 | Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. | Glycerate kinase; Belongs to the glycerate kinase type-2 family. | 0.935 |
BPGM | GPI | ENSP00000376840 | ENSP00000405573 | Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. | Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. | 0.945 |
BPGM | PGAM1 | ENSP00000376840 | ENSP00000359991 | Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. | Phosphoglycerate mutase 1; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. | 0.966 |
BPGM | PGAM2 | ENSP00000376840 | ENSP00000297283 | Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. | Phosphoglycerate mutase 2; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. | 0.968 |
BPGM | PGAM4 | ENSP00000376840 | ENSP00000412189 | Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. | Phosphoglycerate mutase family member 4. | 0.940 |
BPGM | PKLR | ENSP00000376840 | ENSP00000339933 | Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. | Pyruvate kinase PKLR; Plays a key role in glycolysis. | 0.733 |
BPGM | PKM | ENSP00000376840 | ENSP00000320171 | Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation a [...] | 0.700 |
ENO4 | BPGM | ENSP00000345555 | ENSP00000376840 | Enolase 4; May be required for sperm motility and function. | Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. | 0.960 |
ENO4 | GLYCTK | ENSP00000345555 | ENSP00000389175 | Enolase 4; May be required for sperm motility and function. | Glycerate kinase; Belongs to the glycerate kinase type-2 family. | 0.938 |
ENO4 | GPI | ENSP00000345555 | ENSP00000405573 | Enolase 4; May be required for sperm motility and function. | Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. | 0.973 |
ENO4 | PCK1 | ENSP00000345555 | ENSP00000319814 | Enolase 4; May be required for sperm motility and function. | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. Belongs to the phosphoenolpyruvate carboxykinase [...] | 0.956 |
ENO4 | PCK2 | ENSP00000345555 | ENSP00000216780 | Enolase 4; May be required for sperm motility and function. | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.955 |
ENO4 | PGAM1 | ENSP00000345555 | ENSP00000359991 | Enolase 4; May be required for sperm motility and function. | Phosphoglycerate mutase 1; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. | 0.973 |
ENO4 | PGAM2 | ENSP00000345555 | ENSP00000297283 | Enolase 4; May be required for sperm motility and function. | Phosphoglycerate mutase 2; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. | 0.976 |
ENO4 | PGAM4 | ENSP00000345555 | ENSP00000412189 | Enolase 4; May be required for sperm motility and function. | Phosphoglycerate mutase family member 4. | 0.958 |
ENO4 | PKLR | ENSP00000345555 | ENSP00000339933 | Enolase 4; May be required for sperm motility and function. | Pyruvate kinase PKLR; Plays a key role in glycolysis. | 0.984 |
ENO4 | PKM | ENSP00000345555 | ENSP00000320171 | Enolase 4; May be required for sperm motility and function. | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation a [...] | 0.979 |
GLYCTK | BPGM | ENSP00000389175 | ENSP00000376840 | Glycerate kinase; Belongs to the glycerate kinase type-2 family. | Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. | 0.935 |
GLYCTK | ENO4 | ENSP00000389175 | ENSP00000345555 | Glycerate kinase; Belongs to the glycerate kinase type-2 family. | Enolase 4; May be required for sperm motility and function. | 0.938 |