node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf68 | EVA1B | ENSP00000398350 | ENSP00000270824 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68. | Eva-1 homolog B; Belongs to the EVA1 family. | 0.470 |
CMPK2 | EVA1B | ENSP00000256722 | ENSP00000270824 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. | Eva-1 homolog B; Belongs to the EVA1 family. | 0.442 |
CMPK2 | OASL | ENSP00000256722 | ENSP00000257570 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. | 2'-5'-oligoadenylate synthase-like protein; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family. | 0.722 |
CMPK2 | SLFN13 | ENSP00000256722 | ENSP00000285013 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. | Schlafen family member 13; Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. Does not act on tRNA(Sec). Able to restrict HIV-1 virus replication; ability to inhibit HIV-1 replication is dependent on endoribonuclease activity. | 0.458 |
DECR2 | EVA1B | ENSP00000219481 | ENSP00000270824 | Peroxisomal 2,4-dienoyl-CoA reductase; Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. | Eva-1 homolog B; Belongs to the EVA1 family. | 0.427 |
ETNK2 | EVA1B | ENSP00000356169 | ENSP00000270824 | Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity). | Eva-1 homolog B; Belongs to the EVA1 family. | 0.407 |
EVA1B | C11orf68 | ENSP00000270824 | ENSP00000398350 | Eva-1 homolog B; Belongs to the EVA1 family. | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68. | 0.470 |
EVA1B | CMPK2 | ENSP00000270824 | ENSP00000256722 | Eva-1 homolog B; Belongs to the EVA1 family. | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. | 0.442 |
EVA1B | DECR2 | ENSP00000270824 | ENSP00000219481 | Eva-1 homolog B; Belongs to the EVA1 family. | Peroxisomal 2,4-dienoyl-CoA reductase; Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. | 0.427 |
EVA1B | ETNK2 | ENSP00000270824 | ENSP00000356169 | Eva-1 homolog B; Belongs to the EVA1 family. | Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity). | 0.407 |
EVA1B | MTG2 | ENSP00000270824 | ENSP00000359859 | Eva-1 homolog B; Belongs to the EVA1 family. | Mitochondrial ribosome-associated GTPase 2; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process. | 0.474 |
EVA1B | OASL | ENSP00000270824 | ENSP00000257570 | Eva-1 homolog B; Belongs to the EVA1 family. | 2'-5'-oligoadenylate synthase-like protein; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family. | 0.400 |
EVA1B | SH3D21 | ENSP00000270824 | ENSP00000421294 | Eva-1 homolog B; Belongs to the EVA1 family. | SH3 domain containing 21. | 0.514 |
EVA1B | SLFN13 | ENSP00000270824 | ENSP00000285013 | Eva-1 homolog B; Belongs to the EVA1 family. | Schlafen family member 13; Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. Does not act on tRNA(Sec). Able to restrict HIV-1 virus replication; ability to inhibit HIV-1 replication is dependent on endoribonuclease activity. | 0.767 |
EVA1B | TMEM252 | ENSP00000270824 | ENSP00000366528 | Eva-1 homolog B; Belongs to the EVA1 family. | Transmembrane protein 252. | 0.410 |
EVA1B | XPNPEP3 | ENSP00000270824 | ENSP00000349658 | Eva-1 homolog B; Belongs to the EVA1 family. | Xaa-Pro aminopeptidase 3; Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. | 0.404 |
MTG2 | EVA1B | ENSP00000359859 | ENSP00000270824 | Mitochondrial ribosome-associated GTPase 2; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process. | Eva-1 homolog B; Belongs to the EVA1 family. | 0.474 |
OASL | CMPK2 | ENSP00000257570 | ENSP00000256722 | 2'-5'-oligoadenylate synthase-like protein; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family. | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. | 0.722 |
OASL | EVA1B | ENSP00000257570 | ENSP00000270824 | 2'-5'-oligoadenylate synthase-like protein; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family. | Eva-1 homolog B; Belongs to the EVA1 family. | 0.400 |
OASL | SLFN13 | ENSP00000257570 | ENSP00000285013 | 2'-5'-oligoadenylate synthase-like protein; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family. | Schlafen family member 13; Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. Does not act on tRNA(Sec). Able to restrict HIV-1 virus replication; ability to inhibit HIV-1 replication is dependent on endoribonuclease activity. | 0.487 |