node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EVX1 | FOXB1 | ENSP00000419266 | ENSP00000379369 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | Forkhead box B1. | 0.484 |
EVX1 | GRIN1 | ENSP00000419266 | ENSP00000360608 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. | 0.548 |
EVX1 | ISL1 | ENSP00000419266 | ENSP00000230658 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | 0.759 |
EVX1 | ISL2 | ENSP00000419266 | ENSP00000290759 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. | 0.644 |
EVX1 | LHX1 | ENSP00000419266 | ENSP00000477829 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | 0.757 |
EVX1 | LHX3 | ENSP00000419266 | ENSP00000360811 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | LIM/homeobox protein Lhx3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. | 0.519 |
EVX1 | PAX2 | ENSP00000419266 | ENSP00000359319 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS. | 0.492 |
EVX1 | RAB2A | ENSP00000419266 | ENSP00000262646 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. | 0.564 |
EVX1 | SPOP | ENSP00000419266 | ENSP00000377001 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] | 0.685 |
EVX1 | ZNF180 | ENSP00000419266 | ENSP00000221327 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | Zinc finger protein 180; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.542 |
FOXB1 | EVX1 | ENSP00000379369 | ENSP00000419266 | Forkhead box B1. | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | 0.484 |
FOXB1 | LHX1 | ENSP00000379369 | ENSP00000477829 | Forkhead box B1. | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | 0.471 |
GRIN1 | EVX1 | ENSP00000360608 | ENSP00000419266 | Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | 0.548 |
ISL1 | EVX1 | ENSP00000230658 | ENSP00000419266 | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | 0.759 |
ISL1 | LHX3 | ENSP00000230658 | ENSP00000360811 | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | LIM/homeobox protein Lhx3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. | 0.998 |
ISL1 | PAX2 | ENSP00000230658 | ENSP00000359319 | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS. | 0.648 |
ISL1 | RAB2A | ENSP00000230658 | ENSP00000262646 | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. | 0.554 |
ISL2 | EVX1 | ENSP00000290759 | ENSP00000419266 | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | 0.644 |
ISL2 | LHX3 | ENSP00000290759 | ENSP00000360811 | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. | LIM/homeobox protein Lhx3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. | 0.942 |
ISL2 | PAX2 | ENSP00000290759 | ENSP00000359319 | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS. | 0.430 |