node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C19orf18 | FAM177A1 | ENSP00000321519 | ENSP00000280987 | Uncharacterized protein C19orf18; Chromosome 19 open reading frame 18. | Protein FAM177A1; Family with sequence similarity 177 member A1. | 0.447 |
FAM177A1 | C19orf18 | ENSP00000280987 | ENSP00000321519 | Protein FAM177A1; Family with sequence similarity 177 member A1. | Uncharacterized protein C19orf18; Chromosome 19 open reading frame 18. | 0.447 |
FAM177A1 | FAM204A | ENSP00000280987 | ENSP00000358183 | Protein FAM177A1; Family with sequence similarity 177 member A1. | Protein FAM204A; Family with sequence similarity 204 member A. | 0.473 |
FAM177A1 | FAM222B | ENSP00000280987 | ENSP00000462419 | Protein FAM177A1; Family with sequence similarity 177 member A1. | Protein FAM222B; Family with sequence similarity 222 member B; Belongs to the FAM222 family. | 0.430 |
FAM177A1 | KRTAP13-4 | ENSP00000280987 | ENSP00000334834 | Protein FAM177A1; Family with sequence similarity 177 member A1. | Keratin-associated protein 13-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the PMG family. | 0.506 |
FAM177A1 | MED29 | ENSP00000280987 | ENSP00000481733 | Protein FAM177A1; Family with sequence similarity 177 member A1. | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.441 |
FAM177A1 | ODR4 | ENSP00000280987 | ENSP00000287859 | Protein FAM177A1; Family with sequence similarity 177 member A1. | Protein odr-4 homolog; May play a role in the trafficking of a subset of G-protein coupled receptors; Belongs to the ODR-4 family. | 0.467 |
FAM177A1 | RHOJ | ENSP00000280987 | ENSP00000316729 | Protein FAM177A1; Family with sequence similarity 177 member A1. | Rho-related GTP-binding protein RhoJ; Plasma membrane-associated small GTPase specifically involved in angiogenesis. Required for endothelial cell migration during vascular development via its interaction with GLUL. Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration. | 0.444 |
FAM177A1 | SRP54 | ENSP00000280987 | ENSP00000451818 | Protein FAM177A1; Family with sequence similarity 177 member A1. | Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). | 0.541 |
FAM177A1 | SYAP1 | ENSP00000280987 | ENSP00000369500 | Protein FAM177A1; Family with sequence similarity 177 member A1. | Synapse-associated protein 1; Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation. | 0.437 |
FAM177A1 | VPS13B | ENSP00000280987 | ENSP00000351346 | Protein FAM177A1; Family with sequence similarity 177 member A1. | Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family. | 0.457 |
FAM204A | FAM177A1 | ENSP00000358183 | ENSP00000280987 | Protein FAM204A; Family with sequence similarity 204 member A. | Protein FAM177A1; Family with sequence similarity 177 member A1. | 0.473 |
FAM222B | FAM177A1 | ENSP00000462419 | ENSP00000280987 | Protein FAM222B; Family with sequence similarity 222 member B; Belongs to the FAM222 family. | Protein FAM177A1; Family with sequence similarity 177 member A1. | 0.430 |
KRTAP13-4 | FAM177A1 | ENSP00000334834 | ENSP00000280987 | Keratin-associated protein 13-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the PMG family. | Protein FAM177A1; Family with sequence similarity 177 member A1. | 0.506 |
MED29 | FAM177A1 | ENSP00000481733 | ENSP00000280987 | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Protein FAM177A1; Family with sequence similarity 177 member A1. | 0.441 |
ODR4 | FAM177A1 | ENSP00000287859 | ENSP00000280987 | Protein odr-4 homolog; May play a role in the trafficking of a subset of G-protein coupled receptors; Belongs to the ODR-4 family. | Protein FAM177A1; Family with sequence similarity 177 member A1. | 0.467 |
RHOJ | FAM177A1 | ENSP00000316729 | ENSP00000280987 | Rho-related GTP-binding protein RhoJ; Plasma membrane-associated small GTPase specifically involved in angiogenesis. Required for endothelial cell migration during vascular development via its interaction with GLUL. Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration. | Protein FAM177A1; Family with sequence similarity 177 member A1. | 0.444 |
SRP54 | FAM177A1 | ENSP00000451818 | ENSP00000280987 | Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). | Protein FAM177A1; Family with sequence similarity 177 member A1. | 0.541 |
SYAP1 | FAM177A1 | ENSP00000369500 | ENSP00000280987 | Synapse-associated protein 1; Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation. | Protein FAM177A1; Family with sequence similarity 177 member A1. | 0.437 |
VPS13B | FAM177A1 | ENSP00000351346 | ENSP00000280987 | Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family. | Protein FAM177A1; Family with sequence similarity 177 member A1. | 0.457 |