node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCTN2 | DCTN4 | ENSP00000408910 | ENSP00000414906 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | 0.999 |
DCTN2 | FAM193A | ENSP00000408910 | ENSP00000324587 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | 0.756 |
DCTN4 | DCTN2 | ENSP00000414906 | ENSP00000408910 | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. | 0.999 |
DCTN4 | FAM193A | ENSP00000414906 | ENSP00000324587 | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | 0.407 |
EIF4ENIF1 | FAM193A | ENSP00000380659 | ENSP00000324587 | Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism. | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | 0.469 |
EIF4ENIF1 | TAF1 | ENSP00000380659 | ENSP00000406549 | Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism. | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family. | 0.620 |
FAM193A | DCTN2 | ENSP00000324587 | ENSP00000408910 | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. | 0.756 |
FAM193A | DCTN4 | ENSP00000324587 | ENSP00000414906 | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | 0.407 |
FAM193A | EIF4ENIF1 | ENSP00000324587 | ENSP00000380659 | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism. | 0.469 |
FAM193A | MDM4 | ENSP00000324587 | ENSP00000356150 | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions; Belongs to the MDM2/MDM4 family. | 0.414 |
FAM193A | NOP14 | ENSP00000324587 | ENSP00000405068 | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity); Belongs to the NOP14 family. | 0.482 |
FAM193A | SH3BP2 | ENSP00000324587 | ENSP00000424846 | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | SH3 domain-binding protein 2; Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. | 0.459 |
FAM193A | TAF1 | ENSP00000324587 | ENSP00000406549 | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family. | 0.556 |
FAM193A | ZNF318 | ENSP00000324587 | ENSP00000354964 | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | Zinc finger protein 318; [Isoform 2]: Acts as a transcriptional corepressor for AR- mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. | 0.545 |
MDM4 | FAM193A | ENSP00000356150 | ENSP00000324587 | Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions; Belongs to the MDM2/MDM4 family. | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | 0.414 |
NOP14 | FAM193A | ENSP00000405068 | ENSP00000324587 | Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity); Belongs to the NOP14 family. | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | 0.482 |
SH3BP2 | FAM193A | ENSP00000424846 | ENSP00000324587 | SH3 domain-binding protein 2; Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | 0.459 |
SH3BP2 | TAF1 | ENSP00000424846 | ENSP00000406549 | SH3 domain-binding protein 2; Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family. | 0.432 |
TAF1 | EIF4ENIF1 | ENSP00000406549 | ENSP00000380659 | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family. | Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism. | 0.620 |
TAF1 | FAM193A | ENSP00000406549 | ENSP00000324587 | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family. | Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family. | 0.556 |