node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLASRP | FAM193B | ENSP00000221455 | ENSP00000422131 | CLK4-associating serine/arginine rich protein; Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | 0.511 |
CUL3 | FAM193B | ENSP00000264414 | ENSP00000422131 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | 0.431 |
CUL3 | KCTD5 | ENSP00000264414 | ENSP00000301738 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | BTB/POZ domain-containing protein KCTD5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4. | 0.998 |
DDX41 | FAM193B | ENSP00000330349 | ENSP00000422131 | Probable ATP-dependent RNA helicase DDX41; Probable ATP-dependent RNA helicase. Is required during post- transcriptional gene expression. May be involved in pre-mRNA splicing. Belongs to the DEAD box helicase family. DDX41 subfamily. | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | 0.465 |
ERICH5 | FAM193B | ENSP00000315614 | ENSP00000422131 | Glutamate-rich protein 5; Glutamate rich 5. | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | 0.448 |
ERICH5 | LRRC45 | ENSP00000315614 | ENSP00000306760 | Glutamate-rich protein 5; Glutamate rich 5. | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. | 0.555 |
FAM193B | CLASRP | ENSP00000422131 | ENSP00000221455 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | CLK4-associating serine/arginine rich protein; Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). | 0.511 |
FAM193B | CUL3 | ENSP00000422131 | ENSP00000264414 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | 0.431 |
FAM193B | DDX41 | ENSP00000422131 | ENSP00000330349 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | Probable ATP-dependent RNA helicase DDX41; Probable ATP-dependent RNA helicase. Is required during post- transcriptional gene expression. May be involved in pre-mRNA splicing. Belongs to the DEAD box helicase family. DDX41 subfamily. | 0.465 |
FAM193B | ERICH5 | ENSP00000422131 | ENSP00000315614 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | Glutamate-rich protein 5; Glutamate rich 5. | 0.448 |
FAM193B | KCTD5 | ENSP00000422131 | ENSP00000301738 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | BTB/POZ domain-containing protein KCTD5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4. | 0.480 |
FAM193B | LRCH4 | ENSP00000422131 | ENSP00000309689 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | Leucine rich repeats and calponin homology domain containing 4. | 0.451 |
FAM193B | LRRC45 | ENSP00000422131 | ENSP00000306760 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. | 0.410 |
FAM193B | PRR7 | ENSP00000422131 | ENSP00000327168 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | Proline-rich protein 7; Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN. Might play a redundant role in the regulation of T cell receptor signaling. Might promote apoptosis in T cells. | 0.498 |
FAM193B | TMED9 | ENSP00000422131 | ENSP00000330945 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | Transmembrane emp24 domain-containing protein 9; Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of t [...] | 0.446 |
FAM193B | TRIM10 | ENSP00000422131 | ENSP00000397073 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | Tripartite motif-containing protein 10; Seems to play an important role in erythropoiesis. Belongs to the TRIM/RBCC family. | 0.525 |
KCTD5 | CUL3 | ENSP00000301738 | ENSP00000264414 | BTB/POZ domain-containing protein KCTD5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4. | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | 0.998 |
KCTD5 | FAM193B | ENSP00000301738 | ENSP00000422131 | BTB/POZ domain-containing protein KCTD5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4. | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | 0.480 |
LRCH4 | FAM193B | ENSP00000309689 | ENSP00000422131 | Leucine rich repeats and calponin homology domain containing 4. | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | 0.451 |
LRRC45 | ERICH5 | ENSP00000306760 | ENSP00000315614 | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. | Glutamate-rich protein 5; Glutamate rich 5. | 0.555 |