STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM81AProtein FAM81A; Family with sequence similarity 81 member A; Belongs to the FAM81 family. (368 aa)    
Predicted Functional Partners:
OR5C1
Olfactory receptor 5C1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
    
   0.596
OR52B2
Olfactory receptor 52B2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
    
   0.591
PTPN20
Tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.
      
 0.530
C9orf153
Uncharacterized protein C9orf153; Chromosome 9 open reading frame 153.
      
 0.507
LMBR1L
Protein LMBR1L; Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis. Belongs to the LIMR family.
      
 0.502
TMEM179
Transmembrane protein 179; Belongs to the TMEM179 family.
   
  
 0.475
CDRT1
CMT1A duplicated region transcript 1.
      
 0.471
GPR171
Probable G-protein coupled receptor 171; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.463
TOR2A
Torsin-2A; Torsin family 2 member A; Belongs to the ClpA/ClpB family. Torsin subfamily.
      
 0.462
TMEM88B
Transmembrane protein 88B.
   
  
 0.460
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.