node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTNNB1 | FAT1 | ENSP00000495360 | ENSP00000406229 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | 0.933 |
CTNNB1 | NPHS1 | ENSP00000495360 | ENSP00000368190 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Nephrin; Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity). | 0.551 |
CTNNB1 | SCRIB | ENSP00000495360 | ENSP00000349486 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicle [...] | 0.880 |
CTNNB1 | VASP | ENSP00000495360 | ENSP00000245932 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...] | 0.700 |
FAT1 | CTNNB1 | ENSP00000406229 | ENSP00000495360 | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.933 |
FAT1 | FJX1 | ENSP00000406229 | ENSP00000400223 | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | Four-jointed box protein 1; Acts as an inhibitor of dendrite extension and branching. Belongs to the FJX1/FJ family. | 0.844 |
FAT1 | KIRREL1 | ENSP00000406229 | ENSP00000352138 | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | Kin of IRRE-like protein 1; Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity); Belongs to the immunoglobulin superfamily. | 0.921 |
FAT1 | LAMC1 | ENSP00000406229 | ENSP00000258341 | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | 0.799 |
FAT1 | MTNR1A | ENSP00000406229 | ENSP00000302811 | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | Melatonin receptor type 1A; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family. | 0.871 |
FAT1 | MTNR1B | ENSP00000406229 | ENSP00000257068 | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | Melatonin receptor type 1B; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. | 0.720 |
FAT1 | NPHS1 | ENSP00000406229 | ENSP00000368190 | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | Nephrin; Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity). | 0.932 |
FAT1 | NPHS2 | ENSP00000406229 | ENSP00000356587 | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | Podocin; Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. | 0.930 |
FAT1 | SCRIB | ENSP00000406229 | ENSP00000349486 | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicle [...] | 0.908 |
FAT1 | VASP | ENSP00000406229 | ENSP00000245932 | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...] | 0.951 |
FJX1 | FAT1 | ENSP00000400223 | ENSP00000406229 | Four-jointed box protein 1; Acts as an inhibitor of dendrite extension and branching. Belongs to the FJX1/FJ family. | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | 0.844 |
KIRREL1 | FAT1 | ENSP00000352138 | ENSP00000406229 | Kin of IRRE-like protein 1; Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity); Belongs to the immunoglobulin superfamily. | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | 0.921 |
KIRREL1 | NPHS1 | ENSP00000352138 | ENSP00000368190 | Kin of IRRE-like protein 1; Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity); Belongs to the immunoglobulin superfamily. | Nephrin; Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity). | 0.999 |
KIRREL1 | NPHS2 | ENSP00000352138 | ENSP00000356587 | Kin of IRRE-like protein 1; Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity); Belongs to the immunoglobulin superfamily. | Podocin; Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. | 0.999 |
LAMC1 | FAT1 | ENSP00000258341 | ENSP00000406229 | Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | 0.799 |
MTNR1A | FAT1 | ENSP00000302811 | ENSP00000406229 | Melatonin receptor type 1A; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family. | Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. | 0.871 |