node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNC | COQ3 | ENSP00000428982 | ENSP00000254759 | Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphoryla [...] | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. | 0.409 |
CCNC | FAXC | ENSP00000428982 | ENSP00000374328 | Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphoryla [...] | Failed axon connections homolog; May play a role in axonal development. | 0.482 |
CCNC | PNISR | ENSP00000428982 | ENSP00000496842 | Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphoryla [...] | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | 0.449 |
COQ3 | CCNC | ENSP00000254759 | ENSP00000428982 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. | Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphoryla [...] | 0.409 |
COQ3 | FAXC | ENSP00000254759 | ENSP00000374328 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. | Failed axon connections homolog; May play a role in axonal development. | 0.605 |
COQ3 | FBXL4 | ENSP00000254759 | ENSP00000358247 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. | F-box and leucine rich repeat protein 4. | 0.438 |
COQ3 | PNISR | ENSP00000254759 | ENSP00000496842 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | 0.458 |
COQ3 | USP45 | ENSP00000254759 | ENSP00000333376 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. | Ubiquitin carboxyl-terminal hydrolase 45; May be involved in the maintenance of photoreceptor function. | 0.505 |
DSTYK | FAXC | ENSP00000356130 | ENSP00000374328 | Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. | Failed axon connections homolog; May play a role in axonal development. | 0.535 |
DSTYK | NUFIP2 | ENSP00000356130 | ENSP00000225388 | Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. | Nuclear fragile X mental retardation-interacting protein 2; Binds RNA. | 0.437 |
DSTYK | QSER1 | ENSP00000356130 | ENSP00000382241 | Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. | Glutamine and serine rich 1. | 0.464 |
DSTYK | TMTC2 | ENSP00000356130 | ENSP00000322300 | Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. | Protein O-mannosyl-transferase TMTC2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3. | 0.476 |
FAXC | CCNC | ENSP00000374328 | ENSP00000428982 | Failed axon connections homolog; May play a role in axonal development. | Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphoryla [...] | 0.482 |
FAXC | COQ3 | ENSP00000374328 | ENSP00000254759 | Failed axon connections homolog; May play a role in axonal development. | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. | 0.605 |
FAXC | DSTYK | ENSP00000374328 | ENSP00000356130 | Failed axon connections homolog; May play a role in axonal development. | Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. | 0.535 |
FAXC | FBXL4 | ENSP00000374328 | ENSP00000358247 | Failed axon connections homolog; May play a role in axonal development. | F-box and leucine rich repeat protein 4. | 0.553 |
FAXC | NUFIP2 | ENSP00000374328 | ENSP00000225388 | Failed axon connections homolog; May play a role in axonal development. | Nuclear fragile X mental retardation-interacting protein 2; Binds RNA. | 0.499 |
FAXC | PNISR | ENSP00000374328 | ENSP00000496842 | Failed axon connections homolog; May play a role in axonal development. | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | 0.570 |
FAXC | QSER1 | ENSP00000374328 | ENSP00000382241 | Failed axon connections homolog; May play a role in axonal development. | Glutamine and serine rich 1. | 0.556 |
FAXC | TEX9 | ENSP00000374328 | ENSP00000342169 | Failed axon connections homolog; May play a role in axonal development. | Testis-expressed protein 9; Testis expressed 9. | 0.542 |