node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIMP2 | FHL3 | ENSP00000223029 | ENSP00000362107 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | 0.620 |
CCAR1 | FHL3 | ENSP00000265872 | ENSP00000362107 | Cell division cycle and apoptosis regulator protein 1; Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apopto [...] | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | 0.603 |
FHL2 | FHL3 | ENSP00000386892 | ENSP00000362107 | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | 0.534 |
FHL2 | INPP5A | ENSP00000386892 | ENSP00000357583 | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | Inositol polyphosphate-5-phosphatase A; Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. | 0.526 |
FHL3 | AIMP2 | ENSP00000362107 | ENSP00000223029 | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | 0.620 |
FHL3 | CCAR1 | ENSP00000362107 | ENSP00000265872 | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | Cell division cycle and apoptosis regulator protein 1; Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apopto [...] | 0.603 |
FHL3 | FHL2 | ENSP00000362107 | ENSP00000386892 | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | 0.534 |
FHL3 | GCM2 | ENSP00000362107 | ENSP00000368805 | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | Chorion-specific transcription factor GCMb; Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development. | 0.623 |
FHL3 | HIPK1 | ENSP00000362107 | ENSP00000407442 | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | Homeodomain-interacting protein kinase 1; Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by [...] | 0.643 |
FHL3 | INPP5A | ENSP00000362107 | ENSP00000357583 | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | Inositol polyphosphate-5-phosphatase A; Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. | 0.787 |
FHL3 | KLF3 | ENSP00000362107 | ENSP00000261438 | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | Krueppel-like factor 3; Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.823 |
FHL3 | NUDCD1 | ENSP00000362107 | ENSP00000239690 | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | NudC domain containing 1. | 0.619 |
FHL3 | RBPJ | ENSP00000362107 | ENSP00000345206 | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...] | 0.587 |
FHL3 | ZNF512B | ENSP00000362107 | ENSP00000358904 | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | Zinc finger protein 512B; May be involved in transcriptional regulation. | 0.526 |
GCM2 | FHL3 | ENSP00000368805 | ENSP00000362107 | Chorion-specific transcription factor GCMb; Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development. | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | 0.623 |
HIPK1 | FHL3 | ENSP00000407442 | ENSP00000362107 | Homeodomain-interacting protein kinase 1; Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by [...] | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | 0.643 |
INPP5A | FHL2 | ENSP00000357583 | ENSP00000386892 | Inositol polyphosphate-5-phosphatase A; Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | 0.526 |
INPP5A | FHL3 | ENSP00000357583 | ENSP00000362107 | Inositol polyphosphate-5-phosphatase A; Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | 0.787 |
INPP5A | RBPJ | ENSP00000357583 | ENSP00000345206 | Inositol polyphosphate-5-phosphatase A; Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. | Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...] | 0.465 |
KLF3 | FHL3 | ENSP00000261438 | ENSP00000362107 | Krueppel-like factor 3; Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family. | Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. | 0.823 |