node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGTR2 | FNDC3B | ENSP00000360973 | ENSP00000411242 | Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | 0.497 |
ARPC1B | FNDC3B | ENSP00000389631 | ENSP00000411242 | Actin-related protein 2/3 complex subunit 1B; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DN [...] | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | 0.516 |
FNDC3B | AGTR2 | ENSP00000411242 | ENSP00000360973 | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. | 0.497 |
FNDC3B | ARPC1B | ENSP00000411242 | ENSP00000389631 | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | Actin-related protein 2/3 complex subunit 1B; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DN [...] | 0.516 |
FNDC3B | GAS7 | ENSP00000411242 | ENSP00000407552 | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | 0.517 |
FNDC3B | GMDS | ENSP00000411242 | ENSP00000370194 | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. | 0.531 |
FNDC3B | LNX1 | ENSP00000411242 | ENSP00000263925 | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | E3 ubiquitin-protein ligase LNX; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. | 0.496 |
FNDC3B | MPDZ | ENSP00000411242 | ENSP00000320006 | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. | 0.555 |
FNDC3B | TENT5A | ENSP00000411242 | ENSP00000318298 | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | Terminal nucleotidyltransferase 5A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase. | 0.569 |
FNDC3B | TMCO1 | ENSP00000411242 | ENSP00000480514 | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. | 0.584 |
FNDC3B | TRIP13 | ENSP00000411242 | ENSP00000166345 | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher- order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for [...] | 0.562 |
FNDC3B | ZNF469 | ENSP00000411242 | ENSP00000456500 | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | Zinc finger protein 469; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.621 |
GAS7 | FNDC3B | ENSP00000407552 | ENSP00000411242 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | 0.517 |
GAS7 | GMDS | ENSP00000407552 | ENSP00000370194 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. | 0.621 |
GAS7 | TMCO1 | ENSP00000407552 | ENSP00000480514 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. | 0.748 |
GMDS | FNDC3B | ENSP00000370194 | ENSP00000411242 | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | 0.531 |
GMDS | GAS7 | ENSP00000370194 | ENSP00000407552 | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | 0.621 |
GMDS | TMCO1 | ENSP00000370194 | ENSP00000480514 | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. | 0.612 |
LNX1 | FNDC3B | ENSP00000263925 | ENSP00000411242 | E3 ubiquitin-protein ligase LNX; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis. | 0.496 |
LNX1 | MPDZ | ENSP00000263925 | ENSP00000320006 | E3 ubiquitin-protein ligase LNX; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. | 0.449 |