node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHN2 | CPVL | ENSP00000222792 | ENSP00000387164 | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low- grade to high-grade tumors. | Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation; Belongs to the peptidase S10 family. | 0.703 |
CHN2 | ELMO1 | ENSP00000222792 | ENSP00000312185 | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low- grade to high-grade tumors. | Engulfment and cell motility protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. | 0.411 |
CHN2 | FRMD3 | ENSP00000222792 | ENSP00000303508 | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low- grade to high-grade tumors. | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | 0.624 |
CHN2-2 | CPVL | ENSP00000495614 | ENSP00000387164 | Beta-chimaerin. | Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation; Belongs to the peptidase S10 family. | 0.692 |
CHN2-2 | ELMO1 | ENSP00000495614 | ENSP00000312185 | Beta-chimaerin. | Engulfment and cell motility protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. | 0.407 |
CHN2-2 | FRMD3 | ENSP00000495614 | ENSP00000303508 | Beta-chimaerin. | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | 0.663 |
CPVL | CHN2 | ENSP00000387164 | ENSP00000222792 | Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation; Belongs to the peptidase S10 family. | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low- grade to high-grade tumors. | 0.703 |
CPVL | CHN2-2 | ENSP00000387164 | ENSP00000495614 | Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation; Belongs to the peptidase S10 family. | Beta-chimaerin. | 0.692 |
CPVL | FRMD3 | ENSP00000387164 | ENSP00000303508 | Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation; Belongs to the peptidase S10 family. | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | 0.670 |
ELMO1 | CHN2 | ENSP00000312185 | ENSP00000222792 | Engulfment and cell motility protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low- grade to high-grade tumors. | 0.411 |
ELMO1 | CHN2-2 | ENSP00000312185 | ENSP00000495614 | Engulfment and cell motility protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. | Beta-chimaerin. | 0.407 |
ELMO1 | FRMD3 | ENSP00000312185 | ENSP00000303508 | Engulfment and cell motility protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | 0.571 |
FRMD3 | CHN2 | ENSP00000303508 | ENSP00000222792 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low- grade to high-grade tumors. | 0.624 |
FRMD3 | CHN2-2 | ENSP00000303508 | ENSP00000495614 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | Beta-chimaerin. | 0.663 |
FRMD3 | CPVL | ENSP00000303508 | ENSP00000387164 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation; Belongs to the peptidase S10 family. | 0.670 |
FRMD3 | ELMO1 | ENSP00000303508 | ENSP00000312185 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | Engulfment and cell motility protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. | 0.571 |
FRMD3 | LRRIQ3 | ENSP00000303508 | ENSP00000346414 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | Leucine rich repeats and IQ motif containing 3. | 0.645 |
FRMD3 | MYH9 | ENSP00000303508 | ENSP00000216181 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10. | 0.635 |
FRMD3 | NIBAN3 | ENSP00000303508 | ENSP00000335040 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | Niban apoptosis regulator 3; Belongs to the Niban family. | 0.596 |
FRMD3 | RASEF | ENSP00000303508 | ENSP00000365630 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP. | 0.621 |