node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFF1 | GAS7 | ENSP00000378578 | ENSP00000407552 | AF4/FMR2 family member 1. | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | 0.597 |
AFF1 | MLLT1 | ENSP00000378578 | ENSP00000252674 | AF4/FMR2 family member 1. | Protein ENL; Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. | 0.999 |
AFF1 | MLLT10 | ENSP00000378578 | ENSP00000307411 | AF4/FMR2 family member 1. | Protein AF-10; Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation. | 0.985 |
AFF1 | MLLT3 | ENSP00000378578 | ENSP00000369695 | AF4/FMR2 family member 1. | Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylate [...] | 0.999 |
ANKRD26 | GAS7 | ENSP00000365255 | ENSP00000407552 | Ankyrin repeat domain-containing protein 26; Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | 0.612 |
ANKRD26 | LACTB | ENSP00000365255 | ENSP00000261893 | Ankyrin repeat domain-containing protein 26; Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. | Serine beta-lactamase-like protein LACTB, mitochondrial; Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cell [...] | 0.549 |
GAS7 | AFF1 | ENSP00000407552 | ENSP00000378578 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | AF4/FMR2 family member 1. | 0.597 |
GAS7 | ANKRD26 | ENSP00000407552 | ENSP00000365255 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Ankyrin repeat domain-containing protein 26; Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. | 0.612 |
GAS7 | GMDS | ENSP00000407552 | ENSP00000370194 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. | 0.621 |
GAS7 | LACTB | ENSP00000407552 | ENSP00000261893 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Serine beta-lactamase-like protein LACTB, mitochondrial; Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cell [...] | 0.689 |
GAS7 | MLLT1 | ENSP00000407552 | ENSP00000252674 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Protein ENL; Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. | 0.638 |
GAS7 | MLLT10 | ENSP00000407552 | ENSP00000307411 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Protein AF-10; Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation. | 0.669 |
GAS7 | MLLT3 | ENSP00000407552 | ENSP00000369695 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylate [...] | 0.626 |
GAS7 | NCKIPSD | ENSP00000407552 | ENSP00000294129 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | NCK-interacting protein with SH3 domain; Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. | 0.656 |
GAS7 | TMCO1 | ENSP00000407552 | ENSP00000480514 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. | 0.748 |
GAS7 | WAS | ENSP00000407552 | ENSP00000365891 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Wiskott-Aldrich syndrome protein; Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) r [...] | 0.676 |
GMDS | GAS7 | ENSP00000370194 | ENSP00000407552 | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | 0.621 |
GMDS | TMCO1 | ENSP00000370194 | ENSP00000480514 | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. | 0.612 |
LACTB | ANKRD26 | ENSP00000261893 | ENSP00000365255 | Serine beta-lactamase-like protein LACTB, mitochondrial; Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cell [...] | Ankyrin repeat domain-containing protein 26; Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. | 0.549 |
LACTB | GAS7 | ENSP00000261893 | ENSP00000407552 | Serine beta-lactamase-like protein LACTB, mitochondrial; Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cell [...] | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | 0.689 |