node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRYZL1 | GATD1 | ENSP00000370966 | ENSP00000321691 | Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | 0.819 |
CRYZL1 | PPP1R21 | ENSP00000370966 | ENSP00000294952 | Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. | Protein phosphatase 1 regulatory subunit 21; Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway. | 0.942 |
DNAAF3 | GATD1 | ENSP00000436975 | ENSP00000321691 | Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia. | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | 0.562 |
DNAAF3 | TNNI3 | ENSP00000436975 | ENSP00000341838 | Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia. | Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.432 |
GATD1 | CRYZL1 | ENSP00000321691 | ENSP00000370966 | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. | 0.819 |
GATD1 | DNAAF3 | ENSP00000321691 | ENSP00000436975 | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia. | 0.562 |
GATD1 | PARK7 | ENSP00000321691 | ENSP00000340278 | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] | 0.561 |
GATD1 | PPP1R21 | ENSP00000321691 | ENSP00000294952 | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | Protein phosphatase 1 regulatory subunit 21; Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway. | 0.918 |
GATD1 | TNNI1 | ENSP00000321691 | ENSP00000354488 | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.562 |
GATD1 | TNNI2 | ENSP00000321691 | ENSP00000371336 | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.562 |
GATD1 | TNNI3 | ENSP00000321691 | ENSP00000341838 | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.562 |
GATD1 | TPM3 | ENSP00000321691 | ENSP00000498577 | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. | 0.523 |
GATD1 | TPM4 | ENSP00000321691 | ENSP00000494125 | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | Tropomyosin alpha-4 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium. | 0.509 |
GATD1 | TRIB3 | ENSP00000321691 | ENSP00000415416 | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | Tribbles homolog 3; Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr- 308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activi [...] | 0.653 |
PARK7 | GATD1 | ENSP00000340278 | ENSP00000321691 | Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | 0.561 |
PARK7 | TPM3 | ENSP00000340278 | ENSP00000498577 | Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] | Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. | 0.425 |
PPP1R21 | CRYZL1 | ENSP00000294952 | ENSP00000370966 | Protein phosphatase 1 regulatory subunit 21; Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway. | Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. | 0.942 |
PPP1R21 | GATD1 | ENSP00000294952 | ENSP00000321691 | Protein phosphatase 1 regulatory subunit 21; Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway. | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | 0.918 |
TNNI1 | GATD1 | ENSP00000354488 | ENSP00000321691 | Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family. | 0.562 |
TNNI1 | TNNI2 | ENSP00000354488 | ENSP00000371336 | Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.662 |