node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC40 | CWF19L2 | ENSP00000357928 | ENSP00000282251 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | 0.998 |
CDC40 | DDX23 | ENSP00000357928 | ENSP00000310723 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | 0.625 |
CDC40 | DHX15 | ENSP00000357928 | ENSP00000336741 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. | 0.999 |
CDC40 | GCFC2 | ENSP00000357928 | ENSP00000318690 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons; Belongs to the GCF family. | 0.829 |
CDC40 | PPIL1 | ENSP00000357928 | ENSP00000362803 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Peptidyl-prolyl cis-trans isomerase-like 1; Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. | 0.999 |
CDC40 | PRPF8 | ENSP00000357928 | ENSP00000460348 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.999 |
CDC40 | RBM8A | ENSP00000357928 | ENSP00000463058 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | RNA-binding protein 8A; Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced [...] | 0.916 |
CDC40 | SYF2 | ENSP00000357928 | ENSP00000236273 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.999 |
CDC40 | TFIP11 | ENSP00000357928 | ENSP00000384421 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] | 0.981 |
CWF19L2 | CDC40 | ENSP00000282251 | ENSP00000357928 | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 0.998 |
CWF19L2 | DHX15 | ENSP00000282251 | ENSP00000336741 | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. | 0.968 |
CWF19L2 | GCFC2 | ENSP00000282251 | ENSP00000318690 | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons; Belongs to the GCF family. | 0.803 |
CWF19L2 | PPIL1 | ENSP00000282251 | ENSP00000362803 | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | Peptidyl-prolyl cis-trans isomerase-like 1; Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. | 0.987 |
CWF19L2 | PRPF8 | ENSP00000282251 | ENSP00000460348 | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.985 |
CWF19L2 | RBM8A | ENSP00000282251 | ENSP00000463058 | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | RNA-binding protein 8A; Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced [...] | 0.504 |
CWF19L2 | SYF2 | ENSP00000282251 | ENSP00000236273 | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.988 |
CWF19L2 | TFIP11 | ENSP00000282251 | ENSP00000384421 | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] | 0.867 |
DDX23 | CDC40 | ENSP00000310723 | ENSP00000357928 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 0.625 |
DDX23 | DHX15 | ENSP00000310723 | ENSP00000336741 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. | 0.809 |
DDX23 | GCFC2 | ENSP00000310723 | ENSP00000318690 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons; Belongs to the GCF family. | 0.786 |