node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIG1 | GIMAP1 | ENSP00000350509 | ENSP00000302833 | Androgen-induced gene 1 protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | 0.532 |
AIG1 | GIMAP2 | ENSP00000350509 | ENSP00000223293 | Androgen-induced gene 1 protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | 0.589 |
AIG1 | GIMAP4 | ENSP00000350509 | ENSP00000419545 | Androgen-induced gene 1 protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.441 |
AIG1 | GIMAP6 | ENSP00000350509 | ENSP00000479580 | Androgen-induced gene 1 protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. | GTPase, IMAP family member 6. | 0.404 |
AIG1 | GIMAP7 | ENSP00000350509 | ENSP00000315474 | Androgen-induced gene 1 protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. | GTPase IMAP family member 7; The dimer has GTPase activity; the active site contains residues from both subunits. | 0.558 |
C2orf78 | GIMAP2 | ENSP00000387124 | ENSP00000223293 | Uncharacterized protein C2orf78; Chromosome 2 open reading frame 78. | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | 0.573 |
CARD16 | GIMAP2 | ENSP00000364858 | ENSP00000223293 | Caspase recruitment domain-containing protein 16; Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF- alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of cas [...] | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | 0.461 |
GIMAP1 | AIG1 | ENSP00000302833 | ENSP00000350509 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | Androgen-induced gene 1 protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. | 0.532 |
GIMAP1 | GIMAP2 | ENSP00000302833 | ENSP00000223293 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | 0.725 |
GIMAP1 | GIMAP4 | ENSP00000302833 | ENSP00000419545 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.818 |
GIMAP1 | GIMAP6 | ENSP00000302833 | ENSP00000479580 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase, IMAP family member 6. | 0.827 |
GIMAP1 | GIMAP7 | ENSP00000302833 | ENSP00000315474 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase IMAP family member 7; The dimer has GTPase activity; the active site contains residues from both subunits. | 0.833 |
GIMAP2 | AIG1 | ENSP00000223293 | ENSP00000350509 | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | Androgen-induced gene 1 protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. | 0.589 |
GIMAP2 | C2orf78 | ENSP00000223293 | ENSP00000387124 | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | Uncharacterized protein C2orf78; Chromosome 2 open reading frame 78. | 0.573 |
GIMAP2 | CARD16 | ENSP00000223293 | ENSP00000364858 | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | Caspase recruitment domain-containing protein 16; Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF- alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of cas [...] | 0.461 |
GIMAP2 | GIMAP1 | ENSP00000223293 | ENSP00000302833 | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | 0.725 |
GIMAP2 | GIMAP4 | ENSP00000223293 | ENSP00000419545 | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.518 |
GIMAP2 | GIMAP6 | ENSP00000223293 | ENSP00000479580 | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | GTPase, IMAP family member 6. | 0.461 |
GIMAP2 | GIMAP7 | ENSP00000223293 | ENSP00000315474 | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | GTPase IMAP family member 7; The dimer has GTPase activity; the active site contains residues from both subunits. | 0.815 |
GIMAP2 | STOM | ENSP00000223293 | ENSP00000286713 | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. | Erythrocyte band 7 integral membrane protein; Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity; Belongs to the band 7/mec-2 family. | 0.471 |