node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGDIB | GLIPR1 | ENSP00000228945 | ENSP00000266659 | Rho GDP-dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members. | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | 0.507 |
ARHGDIB | IQGAP1 | ENSP00000228945 | ENSP00000268182 | Rho GDP-dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members. | Ras GTPase-activating-like protein IQGAP1; Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest. | 0.501 |
ARHGDIB | LAPTM5 | ENSP00000228945 | ENSP00000294507 | Rho GDP-dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members. | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family. | 0.795 |
ARHGDIB | SRGN | ENSP00000228945 | ENSP00000242465 | Rho GDP-dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members. | Serglycin; Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule- mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also r [...] | 0.627 |
FABP1 | GLIPR1 | ENSP00000295834 | ENSP00000266659 | Fatty acid-binding protein, liver; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | 0.505 |
FABP1 | HELZ2 | ENSP00000295834 | ENSP00000417401 | Fatty acid-binding protein, liver; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Helicase with zinc finger domain 2; Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA; Belongs to the DNA2/NAM7 helicase family. | 0.499 |
FABP1 | PPARA | ENSP00000295834 | ENSP00000385523 | Fatty acid-binding protein, liver; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] | 0.964 |
GART | GLIPR1 | ENSP00000371253 | ENSP00000266659 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family. | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | 0.831 |
GART | GLIPR2 | ENSP00000371253 | ENSP00000367196 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family. | Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2. | 0.831 |
GLIPR1 | ARHGDIB | ENSP00000266659 | ENSP00000228945 | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | Rho GDP-dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members. | 0.507 |
GLIPR1 | FABP1 | ENSP00000266659 | ENSP00000295834 | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | Fatty acid-binding protein, liver; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.505 |
GLIPR1 | GART | ENSP00000266659 | ENSP00000371253 | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family. | 0.831 |
GLIPR1 | GLIPR2 | ENSP00000266659 | ENSP00000367196 | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2. | 0.762 |
GLIPR1 | HELZ2 | ENSP00000266659 | ENSP00000417401 | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | Helicase with zinc finger domain 2; Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA; Belongs to the DNA2/NAM7 helicase family. | 0.484 |
GLIPR1 | IQGAP1 | ENSP00000266659 | ENSP00000268182 | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | Ras GTPase-activating-like protein IQGAP1; Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest. | 0.475 |
GLIPR1 | LAPTM5 | ENSP00000266659 | ENSP00000294507 | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family. | 0.635 |
GLIPR1 | PPARA | ENSP00000266659 | ENSP00000385523 | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] | 0.538 |
GLIPR1 | SRGN | ENSP00000266659 | ENSP00000242465 | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | Serglycin; Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule- mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also r [...] | 0.517 |
GLIPR1 | TP53 | ENSP00000266659 | ENSP00000269305 | Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.573 |
GLIPR2 | GART | ENSP00000367196 | ENSP00000371253 | Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2. | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family. | 0.831 |