STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GMCL1Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). (515 aa)    
Predicted Functional Partners:
XAGE2
X antigen family member 2.
    
   0.719
XAGE3
X antigen family member 3.
    
   0.598
GAGE10
G antigen 10; Belongs to the GAGE family.
    
   0.591
FAM167A
Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family.
    
   0.572
GAGE12G
G antigen 12G.
    
 
 0.546
USHBP1
Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1.
    
 
 0.520
SPIN4
Spindlin-4; Exhibits H3K4me3-binding activity. Belongs to the SPIN/STSY family.
   
  
 0.513
GAGE2A
G antigen 2A.
    
 
 0.475
PBXIP1
Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
    
   0.451
GAGE2E
G antigen 2E.
    
   0.420
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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