node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC183 | GPR151 | ENSP00000338013 | ENSP00000308733 | Coiled-coil domain containing 183. | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | 0.599 |
GAL | GPR151 | ENSP00000265643 | ENSP00000308733 | Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | 0.836 |
GPR132 | GPR151 | ENSP00000328818 | ENSP00000308733 | Probable G-protein coupled receptor 132; May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensin [...] | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | 0.464 |
GPR139 | GPR149 | ENSP00000458791 | ENSP00000374390 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.625 |
GPR139 | GPR151 | ENSP00000458791 | ENSP00000308733 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | 0.573 |
GPR139 | GPR31 | ENSP00000458791 | ENSP00000355799 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. | 0.477 |
GPR149 | GPR139 | ENSP00000374390 | ENSP00000458791 | Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | 0.625 |
GPR149 | GPR151 | ENSP00000374390 | ENSP00000308733 | Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | 0.462 |
GPR149 | GPR176 | ENSP00000374390 | ENSP00000453076 | Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist- independent basal activity to repress cAMP production. | 0.491 |
GPR151 | CCDC183 | ENSP00000308733 | ENSP00000338013 | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | Coiled-coil domain containing 183. | 0.599 |
GPR151 | GAL | ENSP00000308733 | ENSP00000265643 | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. | 0.836 |
GPR151 | GPR132 | ENSP00000308733 | ENSP00000328818 | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | Probable G-protein coupled receptor 132; May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensin [...] | 0.464 |
GPR151 | GPR139 | ENSP00000308733 | ENSP00000458791 | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | 0.573 |
GPR151 | GPR149 | ENSP00000308733 | ENSP00000374390 | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.462 |
GPR151 | GPR176 | ENSP00000308733 | ENSP00000453076 | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist- independent basal activity to repress cAMP production. | 0.479 |
GPR151 | GPR31 | ENSP00000308733 | ENSP00000355799 | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. | 0.488 |
GPR151 | GPR75 | ENSP00000308733 | ENSP00000378195 | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | Probable G-protein coupled receptor 75; G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. | 0.528 |
GPR151 | SH3RF2 | ENSP00000308733 | ENSP00000424497 | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | E3 ubiquitin-protein ligase SH3RF2; Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation. Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity. | 0.488 |
GPR151 | TRARG1 | ENSP00000308733 | ENSP00000329548 | G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor. | Trafficking regulator of GLUT4 1; Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. | 0.487 |
GPR176 | GPR149 | ENSP00000453076 | ENSP00000374390 | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist- independent basal activity to repress cAMP production. | Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.491 |