STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPR162Probable G-protein coupled receptor 162; Orphan receptor. (588 aa)    
Predicted Functional Partners:
GPR26
G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
   
  
 0.673
GPR62
G-protein coupled receptor 62; Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways. Has spontaneous activity for beta-arrestin recruitment. Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization.
   
  
 0.584
GPR150
Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.580
GPR68
Ovarian cancer G-protein coupled receptor 1; Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity); Belongs to the G-protein coupled receptor 1 family.
   
  
 0.575
GPR82
Probable G-protein coupled receptor 82; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.560
ADGRA1
Adhesion G protein-coupled receptor A1; Orphan receptor.
   
 
 0.542
GPR146
Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.539
GPR148
Probable G-protein coupled receptor 148; Orphan receptor.
      
 0.526
GPR152
Probable G-protein coupled receptor 152; Orphan receptor.
    
 
 0.526
GPR139
Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
      
 0.518
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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