STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPR176G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist- independent basal activity to repress cAMP production. (515 aa)    
Predicted Functional Partners:
GPR150
Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
     
 0.697
GPR27
Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.
     
 0.649
GPR17
Uracil nucleotide/cysteinyl leukotriene receptor; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.631
GPR25
Probable G-protein coupled receptor 25; Orphan receptor.
     
 0.630
GPR45
Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function.
     
 0.618
GNAS
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity).
    
 0.618
FSIP1
Fibrous sheath interacting protein 1; Belongs to the FSIP1 family.
 
 
    0.610
GPR20
G-protein coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
     
 0.584
GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
    
 
 0.580
GPR153
Probable G-protein coupled receptor 153; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.570
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (26%) [HD]