node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC181 | HAPLN3 | ENSP00000356780 | ENSP00000457180 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | 0.699 |
CCDC181 | ST6GALNAC3 | ENSP00000356780 | ENSP00000329214 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | 0.485 |
CCDC181 | ZNF660 | ENSP00000356780 | ENSP00000324605 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.609 |
EDIL3 | HAPLN3 | ENSP00000296591 | ENSP00000457180 | EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development. | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | 0.419 |
HAPLN3 | CCDC181 | ENSP00000457180 | ENSP00000356780 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | 0.699 |
HAPLN3 | EDIL3 | ENSP00000457180 | ENSP00000296591 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development. | 0.419 |
HAPLN3 | MFGE8 | ENSP00000457180 | ENSP00000268150 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | Lactadherin short form; Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. | 0.526 |
HAPLN3 | ST6GALNAC3 | ENSP00000457180 | ENSP00000329214 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | 0.404 |
HAPLN3 | WARS1 | ENSP00000457180 | ENSP00000347495 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | Tryptophan--tRNA ligase, cytoplasmic; Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress- responsive gene expression. | 0.422 |
HAPLN3 | ZNF660 | ENSP00000457180 | ENSP00000324605 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.544 |
MFGE8 | HAPLN3 | ENSP00000268150 | ENSP00000457180 | Lactadherin short form; Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | 0.526 |
ST6GALNAC3 | CCDC181 | ENSP00000329214 | ENSP00000356780 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | 0.485 |
ST6GALNAC3 | HAPLN3 | ENSP00000329214 | ENSP00000457180 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | 0.404 |
ST6GALNAC3 | ZNF660 | ENSP00000329214 | ENSP00000324605 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.580 |
WARS1 | HAPLN3 | ENSP00000347495 | ENSP00000457180 | Tryptophan--tRNA ligase, cytoplasmic; Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress- responsive gene expression. | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | 0.422 |
ZNF660 | CCDC181 | ENSP00000324605 | ENSP00000356780 | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | 0.609 |
ZNF660 | HAPLN3 | ENSP00000324605 | ENSP00000457180 | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | 0.544 |
ZNF660 | ST6GALNAC3 | ENSP00000324605 | ENSP00000329214 | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | 0.580 |