node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS8 | BCAN | ENSP00000257359 | ENSP00000331210 | A disintegrin and metalloproteinase with thrombospondin motifs 8; Has anti-angiogenic properties. | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans; Belongs to the aggrecan/versican proteoglycan family. | 0.623 |
ADAMTS8 | HAPLN4 | ENSP00000257359 | ENSP00000291481 | A disintegrin and metalloproteinase with thrombospondin motifs 8; Has anti-angiogenic properties. | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | 0.524 |
BCAN | ADAMTS8 | ENSP00000331210 | ENSP00000257359 | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans; Belongs to the aggrecan/versican proteoglycan family. | A disintegrin and metalloproteinase with thrombospondin motifs 8; Has anti-angiogenic properties. | 0.623 |
BCAN | HAPLN4 | ENSP00000331210 | ENSP00000291481 | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans; Belongs to the aggrecan/versican proteoglycan family. | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | 0.669 |
BCAN | NCAN | ENSP00000331210 | ENSP00000252575 | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans; Belongs to the aggrecan/versican proteoglycan family. | Neurocan core protein; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N- CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid; Belongs to the aggrecan/versican proteoglycan family. | 0.955 |
BCAN | PVALB | ENSP00000331210 | ENSP00000216200 | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans; Belongs to the aggrecan/versican proteoglycan family. | Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; Belongs to the parvalbumin family. | 0.653 |
CCDC183 | HAPLN4 | ENSP00000338013 | ENSP00000291481 | Coiled-coil domain containing 183. | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | 0.529 |
CCDC183 | KCNS2 | ENSP00000338013 | ENSP00000287042 | Coiled-coil domain containing 183. | Potassium voltage-gated channel subfamily S member 2; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. | 0.539 |
HAPLN4 | ADAMTS8 | ENSP00000291481 | ENSP00000257359 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | A disintegrin and metalloproteinase with thrombospondin motifs 8; Has anti-angiogenic properties. | 0.524 |
HAPLN4 | BCAN | ENSP00000291481 | ENSP00000331210 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans; Belongs to the aggrecan/versican proteoglycan family. | 0.669 |
HAPLN4 | CCDC183 | ENSP00000291481 | ENSP00000338013 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | Coiled-coil domain containing 183. | 0.529 |
HAPLN4 | IQCF5 | ENSP00000291481 | ENSP00000394653 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | IQ motif containing F5. | 0.557 |
HAPLN4 | KCNC1 | ENSP00000291481 | ENSP00000265969 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action [...] | 0.513 |
HAPLN4 | KCNS2 | ENSP00000291481 | ENSP00000287042 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | Potassium voltage-gated channel subfamily S member 2; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. | 0.671 |
HAPLN4 | NCAN | ENSP00000291481 | ENSP00000252575 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | Neurocan core protein; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N- CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid; Belongs to the aggrecan/versican proteoglycan family. | 0.598 |
HAPLN4 | PVALB | ENSP00000291481 | ENSP00000216200 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; Belongs to the parvalbumin family. | 0.609 |
HAPLN4 | TM6SF1 | ENSP00000291481 | ENSP00000317000 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | 0.948 |
HAPLN4 | TM6SF2 | ENSP00000291481 | ENSP00000374014 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | Transmembrane 6 superfamily member 2; Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase. Belongs to the TM6SF family. | 0.972 |
IQCF5 | HAPLN4 | ENSP00000394653 | ENSP00000291481 | IQ motif containing F5. | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | 0.557 |
KCNC1 | HAPLN4 | ENSP00000265969 | ENSP00000291481 | Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action [...] | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. | 0.513 |