node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AOC1 | HDC | ENSP00000411613 | ENSP00000267845 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function; Belongs to the copper/topaquinone oxidase family. | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. Belongs to the group II decarboxylase family. | 0.963 |
AOC1 | HNMT | ENSP00000411613 | ENSP00000280097 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function; Belongs to the copper/topaquinone oxidase family. | Histamine N-methyltransferase; Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. | 0.990 |
AOC1 | HRH1 | ENSP00000411613 | ENSP00000380247 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function; Belongs to the copper/topaquinone oxidase family. | Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. | 0.445 |
AOC1 | HRH2 | ENSP00000411613 | ENSP00000366506 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function; Belongs to the copper/topaquinone oxidase family. | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.446 |
CARNS1 | CNDP1 | ENSP00000389009 | ENSP00000351682 | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | 0.979 |
CARNS1 | CNDP2 | ENSP00000389009 | ENSP00000325548 | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N-lactoyl-amino acids from lactate [...] | 0.963 |
CARNS1 | HAL | ENSP00000389009 | ENSP00000261208 | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | Histidine ammonia-lyase. | 0.906 |
CARNS1 | HDC | ENSP00000389009 | ENSP00000267845 | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. Belongs to the group II decarboxylase family. | 0.921 |
CNDP1 | CARNS1 | ENSP00000351682 | ENSP00000389009 | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | 0.979 |
CNDP1 | CNDP2 | ENSP00000351682 | ENSP00000325548 | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N-lactoyl-amino acids from lactate [...] | 0.964 |
CNDP1 | HAL | ENSP00000351682 | ENSP00000261208 | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | Histidine ammonia-lyase. | 0.918 |
CNDP1 | HDC | ENSP00000351682 | ENSP00000267845 | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. Belongs to the group II decarboxylase family. | 0.929 |
CNDP2 | CARNS1 | ENSP00000325548 | ENSP00000389009 | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N-lactoyl-amino acids from lactate [...] | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | 0.963 |
CNDP2 | CNDP1 | ENSP00000325548 | ENSP00000351682 | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N-lactoyl-amino acids from lactate [...] | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | 0.964 |
CNDP2 | HAL | ENSP00000325548 | ENSP00000261208 | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N-lactoyl-amino acids from lactate [...] | Histidine ammonia-lyase. | 0.937 |
CNDP2 | HDC | ENSP00000325548 | ENSP00000267845 | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N-lactoyl-amino acids from lactate [...] | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. Belongs to the group II decarboxylase family. | 0.952 |
CPA3 | HDC | ENSP00000296046 | ENSP00000267845 | Carboxypeptidase A3. | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. Belongs to the group II decarboxylase family. | 0.883 |
CPA3 | MS4A2 | ENSP00000296046 | ENSP00000278888 | Carboxypeptidase A3. | High affinity immunoglobulin epsilon receptor subunit beta; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor- bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy; Belongs to the MS4A family. | 0.938 |
HAL | CARNS1 | ENSP00000261208 | ENSP00000389009 | Histidine ammonia-lyase. | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | 0.906 |
HAL | CNDP1 | ENSP00000261208 | ENSP00000351682 | Histidine ammonia-lyase. | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | 0.918 |