node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HRNR | KPRP | ENSP00000357791 | ENSP00000475216 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | Keratinocyte proline rich protein. | 0.659 |
HRNR | S100A1 | ENSP00000357791 | ENSP00000292169 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity. Belongs to the S-100 family. | 0.744 |
HRNR | S100A14 | ENSP00000357791 | ENSP00000357691 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | Protein S100-A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. | 0.798 |
HRNR | S100A2 | ENSP00000357791 | ENSP00000499289 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth. | 0.738 |
HRNR | S100A3 | ENSP00000357791 | ENSP00000357702 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. | 0.762 |
HRNR | S100A4 | ENSP00000357791 | ENSP00000357704 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | S100 calcium binding protein A4. | 0.705 |
HRNR | S100A5 | ENSP00000357791 | ENSP00000357707 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. | 0.732 |
HRNR | S100A6 | ENSP00000357791 | ENSP00000357709 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. | 0.675 |
HRNR | S100A7 | ENSP00000357791 | ENSP00000357711 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | S100 calcium binding protein A7. | 0.672 |
HRNR | S100Z | ENSP00000357791 | ENSP00000320430 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | S100 calcium binding protein Z; Belongs to the S-100 family. | 0.697 |
KPRP | HRNR | ENSP00000475216 | ENSP00000357791 | Keratinocyte proline rich protein. | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | 0.659 |
KPRP | S100A2 | ENSP00000475216 | ENSP00000499289 | Keratinocyte proline rich protein. | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth. | 0.487 |
KPRP | S100A3 | ENSP00000475216 | ENSP00000357702 | Keratinocyte proline rich protein. | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. | 0.503 |
KPRP | S100A4 | ENSP00000475216 | ENSP00000357704 | Keratinocyte proline rich protein. | S100 calcium binding protein A4. | 0.415 |
S100A1 | HRNR | ENSP00000292169 | ENSP00000357791 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity. Belongs to the S-100 family. | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | 0.744 |
S100A1 | S100A14 | ENSP00000292169 | ENSP00000357691 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity. Belongs to the S-100 family. | Protein S100-A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. | 0.570 |
S100A1 | S100A2 | ENSP00000292169 | ENSP00000499289 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity. Belongs to the S-100 family. | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth. | 0.812 |
S100A1 | S100A3 | ENSP00000292169 | ENSP00000357702 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity. Belongs to the S-100 family. | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. | 0.734 |
S100A1 | S100A4 | ENSP00000292169 | ENSP00000357704 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity. Belongs to the S-100 family. | S100 calcium binding protein A4. | 0.807 |
S100A1 | S100A5 | ENSP00000292169 | ENSP00000357707 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity. Belongs to the S-100 family. | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. | 0.512 |