node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJC10 | HTRA4 | ENSP00000264065 | ENSP00000305919 | DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, [...] | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | 0.467 |
DNAJC10 | TCP1 | ENSP00000264065 | ENSP00000317334 | DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, [...] | T-complex protein 1 subunit alpha; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable). | 0.576 |
DNAJC5B | HTRA4 | ENSP00000276570 | ENSP00000305919 | DnaJ heat shock protein family member C5 beta. | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | 0.494 |
GCM1 | HTRA4 | ENSP00000259803 | ENSP00000305919 | Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development. | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | 0.755 |
HTRA4 | DNAJC10 | ENSP00000305919 | ENSP00000264065 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, [...] | 0.467 |
HTRA4 | DNAJC5B | ENSP00000305919 | ENSP00000276570 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | DnaJ heat shock protein family member C5 beta. | 0.494 |
HTRA4 | GCM1 | ENSP00000305919 | ENSP00000259803 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development. | 0.755 |
HTRA4 | INS | ENSP00000305919 | ENSP00000380432 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.483 |
HTRA4 | PLEKHA2 | ENSP00000305919 | ENSP00000482228 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | 0.544 |
HTRA4 | PRSS1 | ENSP00000305919 | ENSP00000308720 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | Alpha-trypsin chain 1; Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates; Belongs to the peptidase S1 family. | 0.703 |
HTRA4 | PRSS58 | ENSP00000305919 | ENSP00000446916 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | Serine protease 58; Belongs to the peptidase S1 family. | 0.768 |
HTRA4 | TCP1 | ENSP00000305919 | ENSP00000317334 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | T-complex protein 1 subunit alpha; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable). | 0.467 |
HTRA4 | TM2D2 | ENSP00000305919 | ENSP00000416050 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | TM2 domain containing 2. | 0.490 |
HTRA4 | XIAP | ENSP00000305919 | ENSP00000360242 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | E3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligas [...] | 0.638 |
INS | HTRA4 | ENSP00000380432 | ENSP00000305919 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | 0.483 |
INS | PRSS1 | ENSP00000380432 | ENSP00000308720 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Alpha-trypsin chain 1; Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates; Belongs to the peptidase S1 family. | 0.466 |
INS | XIAP | ENSP00000380432 | ENSP00000360242 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | E3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligas [...] | 0.445 |
PLEKHA2 | HTRA4 | ENSP00000482228 | ENSP00000305919 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | 0.544 |
PLEKHA2 | TM2D2 | ENSP00000482228 | ENSP00000416050 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | TM2 domain containing 2. | 0.620 |
PRSS1 | HTRA4 | ENSP00000308720 | ENSP00000305919 | Alpha-trypsin chain 1; Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates; Belongs to the peptidase S1 family. | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | 0.703 |