STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C19orf33Immortalization up-regulated protein; Chromosome 19 open reading frame 33 (106 aa)    
Predicted Functional Partners:
SPINT2
Serine peptidase inhibitor, kunitz type 2; Kunitz-type protease inhibitor 2; Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa
   
  
 0.770
PPP1R14A
Protein phosphatase 1 regulatory subunit 14A; Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction
      
 0.767
C4orf19
Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19
      
 0.517
TMEM71
Transmembrane protein 71; Belongs to the TMEM71 family
      
 0.465
C3orf52
TPA-induced transmembrane protein; Chromosome 3 open reading frame 52
      
 0.457
PPP1R12A
Protein phosphatase 1 regulatory subunit 12A; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity; Ankyrin repeat domain containing
      
 0.432
SMIM14
Small integral membrane protein 14
      
 0.414
SAMD14
Sterile alpha motif domain-containing protein 14; Sterile alpha motif domain containing 14
      
 0.404
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (3%) [HD]