node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDKN2A | ISOC2 | ENSP00000418915 | ENSP00000085068 | Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | Isochorismatase domain containing 2. | 0.790 |
ISOC2 | CDKN2A | ENSP00000085068 | ENSP00000418915 | Isochorismatase domain containing 2. | Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | 0.790 |
ISOC2 | IZUMO2 | ENSP00000085068 | ENSP00000293405 | Isochorismatase domain containing 2. | Izumo sperm-egg fusion protein 2; IZUMO family member 2. | 0.573 |
ISOC2 | MROH6 | ENSP00000085068 | ENSP00000381857 | Isochorismatase domain containing 2. | Maestro heat like repeat family member 6. | 0.742 |
ISOC2 | NAPRT | ENSP00000085068 | ENSP00000401508 | Isochorismatase domain containing 2. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis ; Belongs to the NAPRTase family. | 0.748 |
ISOC2 | NMNAT1 | ENSP00000085068 | ENSP00000366410 | Isochorismatase domain containing 2. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...] | 0.571 |
ISOC2 | NMNAT2 | ENSP00000085068 | ENSP00000287713 | Isochorismatase domain containing 2. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substra [...] | 0.564 |
ISOC2 | NMNAT3 | ENSP00000085068 | ENSP00000495112 | Isochorismatase domain containing 2. | Nicotinamide nucleotide adenylyltransferase 3. | 0.564 |
ISOC2 | OPLAH | ENSP00000085068 | ENSP00000480476 | Isochorismatase domain containing 2. | 5-oxoprolinase; Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate; Belongs to the oxoprolinase family. | 0.758 |
ISOC2 | TMEM86B | ENSP00000085068 | ENSP00000321038 | Isochorismatase domain containing 2. | Lysoplasmalogenase; Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties; Belongs to the TMEM86 family. | 0.552 |
ISOC2 | ZNF579 | ENSP00000085068 | ENSP00000320188 | Isochorismatase domain containing 2. | Zinc finger protein 579; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.592 |
IZUMO2 | ISOC2 | ENSP00000293405 | ENSP00000085068 | Izumo sperm-egg fusion protein 2; IZUMO family member 2. | Isochorismatase domain containing 2. | 0.573 |
MROH6 | ISOC2 | ENSP00000381857 | ENSP00000085068 | Maestro heat like repeat family member 6. | Isochorismatase domain containing 2. | 0.742 |
MROH6 | NAPRT | ENSP00000381857 | ENSP00000401508 | Maestro heat like repeat family member 6. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis ; Belongs to the NAPRTase family. | 0.568 |
MROH6 | NMNAT1 | ENSP00000381857 | ENSP00000366410 | Maestro heat like repeat family member 6. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...] | 0.629 |
MROH6 | NMNAT2 | ENSP00000381857 | ENSP00000287713 | Maestro heat like repeat family member 6. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substra [...] | 0.692 |
MROH6 | NMNAT3 | ENSP00000381857 | ENSP00000495112 | Maestro heat like repeat family member 6. | Nicotinamide nucleotide adenylyltransferase 3. | 0.629 |
NAPRT | ISOC2 | ENSP00000401508 | ENSP00000085068 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis ; Belongs to the NAPRTase family. | Isochorismatase domain containing 2. | 0.748 |
NAPRT | MROH6 | ENSP00000401508 | ENSP00000381857 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis ; Belongs to the NAPRTase family. | Maestro heat like repeat family member 6. | 0.568 |
NAPRT | NMNAT1 | ENSP00000401508 | ENSP00000366410 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis ; Belongs to the NAPRTase family. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...] | 0.990 |