node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC73 | KANK3 | ENSP00000335325 | ENSP00000328923 | Coiled-coil domain containing 73. | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | 0.524 |
CLEC14A | HSPA12B | ENSP00000353013 | ENSP00000254963 | C-type lectin domain containing 14A. | Heat shock protein family A member 12B; Belongs to the heat shock protein 70 family. | 0.557 |
CLEC14A | KANK3 | ENSP00000353013 | ENSP00000328923 | C-type lectin domain containing 14A. | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | 0.403 |
CYFIP2 | KANK3 | ENSP00000479719 | ENSP00000328923 | Cytoplasmic FMR1-interacting protein 2; Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | 0.418 |
HSPA12B | CLEC14A | ENSP00000254963 | ENSP00000353013 | Heat shock protein family A member 12B; Belongs to the heat shock protein 70 family. | C-type lectin domain containing 14A. | 0.557 |
HSPA12B | KANK3 | ENSP00000254963 | ENSP00000328923 | Heat shock protein family A member 12B; Belongs to the heat shock protein 70 family. | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | 0.483 |
KANK3 | CCDC73 | ENSP00000328923 | ENSP00000335325 | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | Coiled-coil domain containing 73. | 0.524 |
KANK3 | CLEC14A | ENSP00000328923 | ENSP00000353013 | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | C-type lectin domain containing 14A. | 0.403 |
KANK3 | CYFIP2 | ENSP00000328923 | ENSP00000479719 | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | Cytoplasmic FMR1-interacting protein 2; Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). | 0.418 |
KANK3 | HSPA12B | ENSP00000328923 | ENSP00000254963 | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | Heat shock protein family A member 12B; Belongs to the heat shock protein 70 family. | 0.483 |
KANK3 | PHLDA3 | ENSP00000328923 | ENSP00000356280 | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | Pleckstrin homology-like domain family A member 3; p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. Belongs to the PHLDA3 family. | 0.538 |
KANK3 | PRRG3 | ENSP00000328923 | ENSP00000359378 | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | Transmembrane gamma-carboxyglutamic acid protein 3; Proline rich and Gla domain 3. | 0.416 |
KANK3 | RPS28 | ENSP00000328923 | ENSP00000472469 | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | Ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. | 0.438 |
KANK3 | SULF2 | ENSP00000328923 | ENSP00000353007 | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | Extracellular sulfatase Sulf-2; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin; Belongs to the sulfatase family. | 0.426 |
KANK3 | VCL | ENSP00000328923 | ENSP00000211998 | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. | 0.421 |
KANK3 | ZNF414 | ENSP00000328923 | ENSP00000377504 | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.400 |
PHLDA3 | KANK3 | ENSP00000356280 | ENSP00000328923 | Pleckstrin homology-like domain family A member 3; p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. Belongs to the PHLDA3 family. | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | 0.538 |
PRRG3 | KANK3 | ENSP00000359378 | ENSP00000328923 | Transmembrane gamma-carboxyglutamic acid protein 3; Proline rich and Gla domain 3. | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | 0.416 |
RPS28 | KANK3 | ENSP00000472469 | ENSP00000328923 | Ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | 0.438 |
SULF2 | KANK3 | ENSP00000353007 | ENSP00000328923 | Extracellular sulfatase Sulf-2; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin; Belongs to the sulfatase family. | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization. | 0.426 |