node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C2orf69 | KCTD18 | ENSP00000312770 | ENSP00000352941 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | 0.517 |
C2orf69 | SPATS2L | ENSP00000312770 | ENSP00000482515 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family. | 0.433 |
C2orf69 | TYW5 | ENSP00000312770 | ENSP00000346627 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family. | 0.598 |
KCTD11 | KCTD14 | ENSP00000495203 | ENSP00000316482 | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin- dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of [...] | BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14. | 0.433 |
KCTD11 | KCTD18 | ENSP00000495203 | ENSP00000352941 | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin- dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of [...] | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | 0.478 |
KCTD11 | KCTD2 | ENSP00000495203 | ENSP00000312814 | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin- dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of [...] | BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2. | 0.701 |
KCTD11 | KCTD20 | ENSP00000495203 | ENSP00000362836 | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin- dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of [...] | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | 0.533 |
KCTD14 | KCTD11 | ENSP00000316482 | ENSP00000495203 | BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14. | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin- dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of [...] | 0.433 |
KCTD14 | KCTD18 | ENSP00000316482 | ENSP00000352941 | BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14. | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | 0.479 |
KCTD14 | KCTD19 | ENSP00000316482 | ENSP00000305702 | BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14. | BTB/POZ domain-containing protein KCTD19; Potassium channel tetramerization domain containing 19. | 0.478 |
KCTD14 | KCTD2 | ENSP00000316482 | ENSP00000312814 | BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14. | BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2. | 0.404 |
KCTD14 | KCTD20 | ENSP00000316482 | ENSP00000362836 | BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14. | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | 0.489 |
KCTD18 | C2orf69 | ENSP00000352941 | ENSP00000312770 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | 0.517 |
KCTD18 | KCTD11 | ENSP00000352941 | ENSP00000495203 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin- dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of [...] | 0.478 |
KCTD18 | KCTD14 | ENSP00000352941 | ENSP00000316482 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14. | 0.479 |
KCTD18 | KCTD19 | ENSP00000352941 | ENSP00000305702 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | BTB/POZ domain-containing protein KCTD19; Potassium channel tetramerization domain containing 19. | 0.602 |
KCTD18 | KCTD2 | ENSP00000352941 | ENSP00000312814 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2. | 0.583 |
KCTD18 | KCTD20 | ENSP00000352941 | ENSP00000362836 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | 0.608 |
KCTD18 | L3HYPDH | ENSP00000352941 | ENSP00000247194 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. | 0.481 |
KCTD18 | MINDY4 | ENSP00000352941 | ENSP00000265299 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Belongs to the MINDY deubiquitinase family. FAM188 subfamily. | 0.455 |