STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KPRPKeratinocyte proline rich protein. (579 aa)    
Predicted Functional Partners:
KRT78
Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family.
   
 
 0.791
C1orf68
Skin-specific protein 32; Chromosome 1 open reading frame 68.
   
 
 0.730
SPRR4
Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family.
   
  
 0.694
CRCT1
Cysteine rich C-terminal 1.
   
 
 0.676
LCE3D
Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.
   
 
 0.667
FLG2
Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family.
   
 
 0.666
HRNR
Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family.
   
 
 0.659
SERPINB12
Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily.
   
 
 0.659
CYSRT1
Cysteine rich tail 1.
   
   0.657
LCE3E
Late cornified envelope protein 3E; Precursors of the cornified envelope of the stratum corneum.
   
 
 0.654
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.