STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT78Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family. (520 aa)    
Predicted Functional Partners:
KPRP
Keratinocyte proline rich protein.
   
 
 0.791
CRNN
Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family.
   
  
 0.758
TMPRSS11B
Transmembrane protease serine 11B; Serine protease.
   
 
 0.668
KRT72
Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
   
 
0.649
CYSRT1
Cysteine rich tail 1.
   
 
 0.642
KRT33B
Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family.
   
 
0.637
KRT35
Keratin, type I cuticular Ha5; Keratin 35; Belongs to the intermediate filament family.
   
 
0.618
SPINK7
Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.
   
  
 0.588
KRT4
Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family.
  
 
0.563
LCE3D
Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.
   
  
 0.541
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.