node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC40 | DHX35 | ENSP00000357928 | ENSP00000252011 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | 0.843 |
CDC40 | LENG1 | ENSP00000357928 | ENSP00000222224 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Leukocyte receptor cluster member 1. | 0.845 |
CDC40 | PPIL1 | ENSP00000357928 | ENSP00000362803 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Peptidyl-prolyl cis-trans isomerase-like 1; Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. | 0.999 |
CDC40 | SLU7 | ENSP00000357928 | ENSP00000297151 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. | 0.999 |
CDC40 | SYF2 | ENSP00000357928 | ENSP00000236273 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.999 |
CDC40 | TFIP11 | ENSP00000357928 | ENSP00000384421 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] | 0.981 |
CNOT3 | LENG1 | ENSP00000351159 | ENSP00000222224 | CCR4-NOT transcription complex subunit 3; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic [...] | Leukocyte receptor cluster member 1. | 0.646 |
CNOT3 | MBOAT7 | ENSP00000351159 | ENSP00000245615 | CCR4-NOT transcription complex subunit 3; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic [...] | Lysophospholipid acyltransferase 7; Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1- acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2- diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Required for cortical lamination during brain [...] | 0.468 |
DHX35 | CDC40 | ENSP00000252011 | ENSP00000357928 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 0.843 |
DHX35 | LENG1 | ENSP00000252011 | ENSP00000222224 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | Leukocyte receptor cluster member 1. | 0.604 |
DHX35 | PPIL1 | ENSP00000252011 | ENSP00000362803 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | Peptidyl-prolyl cis-trans isomerase-like 1; Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. | 0.549 |
DHX35 | SLU7 | ENSP00000252011 | ENSP00000297151 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. | 0.815 |
DHX35 | SYF2 | ENSP00000252011 | ENSP00000236273 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.889 |
DHX35 | TFIP11 | ENSP00000252011 | ENSP00000384421 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] | 0.511 |
ESS2 | FRA10AC1 | ENSP00000252137 | ENSP00000360488 | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | Protein FRA10AC1; FRA10A associated CGG repeat 1. | 0.831 |
ESS2 | LENG1 | ENSP00000252137 | ENSP00000222224 | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | Leukocyte receptor cluster member 1. | 0.605 |
ESS2 | SYF2 | ENSP00000252137 | ENSP00000236273 | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.622 |
FRA10AC1 | ESS2 | ENSP00000360488 | ENSP00000252137 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | 0.831 |
FRA10AC1 | LENG1 | ENSP00000360488 | ENSP00000222224 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Leukocyte receptor cluster member 1. | 0.665 |
LENG1 | CDC40 | ENSP00000222224 | ENSP00000357928 | Leukocyte receptor cluster member 1. | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 0.845 |