node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EYA3 | GRAP | ENSP00000362978 | ENSP00000284154 | Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX [...] | GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. | 0.475 |
EYA3 | LIMD2 | ENSP00000362978 | ENSP00000259006 | Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX [...] | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.483 |
FHL2 | LIMD2 | ENSP00000386892 | ENSP00000259006 | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.426 |
GRAP | EYA3 | ENSP00000284154 | ENSP00000362978 | GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. | Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX [...] | 0.475 |
GRAP | LIMD2 | ENSP00000284154 | ENSP00000259006 | GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.638 |
GRAP | MARK2 | ENSP00000284154 | ENSP00000385751 | GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. | Serine/threonine-protein kinase MARK2; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual ac [...] | 0.422 |
GRAP | SPATS2 | ENSP00000284154 | ENSP00000448228 | GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. | Spermatogenesis-associated serine-rich protein 2; Spermatogenesis associated serine rich 2. | 0.447 |
GRAP | TMA7 | ENSP00000284154 | ENSP00000397843 | GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. | Translation machinery associated 7 homolog. | 0.420 |
LIMD2 | EYA3 | ENSP00000259006 | ENSP00000362978 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX [...] | 0.483 |
LIMD2 | FHL2 | ENSP00000259006 | ENSP00000386892 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | 0.426 |
LIMD2 | GRAP | ENSP00000259006 | ENSP00000284154 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. | 0.638 |
LIMD2 | MARK2 | ENSP00000259006 | ENSP00000385751 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Serine/threonine-protein kinase MARK2; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual ac [...] | 0.456 |
LIMD2 | MED14 | ENSP00000259006 | ENSP00000323720 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.483 |
LIMD2 | MPP7 | ENSP00000259006 | ENSP00000337907 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact; Belongs to the MAGUK family. | 0.435 |
LIMD2 | PDLIM2 | ENSP00000259006 | ENSP00000312634 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | PDZ and LIM domain protein 2; Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. | 0.691 |
LIMD2 | SPATS2 | ENSP00000259006 | ENSP00000448228 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Spermatogenesis-associated serine-rich protein 2; Spermatogenesis associated serine rich 2. | 0.433 |
LIMD2 | TMA7 | ENSP00000259006 | ENSP00000397843 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Translation machinery associated 7 homolog. | 0.430 |
LIMD2 | ZNF771 | ENSP00000259006 | ENSP00000323945 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Zinc finger protein 771; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.460 |
MARK2 | GRAP | ENSP00000385751 | ENSP00000284154 | Serine/threonine-protein kinase MARK2; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual ac [...] | GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. | 0.422 |
MARK2 | LIMD2 | ENSP00000385751 | ENSP00000259006 | Serine/threonine-protein kinase MARK2; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual ac [...] | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.456 |