node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIF1AD | LRRC47 | ENSP00000434056 | ENSP00000367498 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47. | 0.926 |
EIF1AD | RIOK1 | ENSP00000434056 | ENSP00000369162 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic associa [...] | 0.977 |
EIF1AD | RPS11 | ENSP00000434056 | ENSP00000270625 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. | 0.832 |
EIF1AD | RPS13 | ENSP00000434056 | ENSP00000435777 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | Ribosomal protein S13. | 0.826 |
EIF1AD | RPS15 | ENSP00000434056 | ENSP00000466010 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | Ribosomal protein S15. | 0.902 |
EIF1AD | RPS3 | ENSP00000434056 | ENSP00000278572 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro- 8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] | 0.833 |
FARS2 | FARSA | ENSP00000316335 | ENSP00000320309 | Phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins; Belongs to the class-II aminoacyl-tRNA synthetase family. | phenylalanyl-tRNA synthetase subunit alpha. | 0.958 |
FARS2 | LRRC47 | ENSP00000316335 | ENSP00000367498 | Phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins; Belongs to the class-II aminoacyl-tRNA synthetase family. | Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47. | 0.937 |
FARS2 | RPS11 | ENSP00000316335 | ENSP00000270625 | Phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins; Belongs to the class-II aminoacyl-tRNA synthetase family. | Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. | 0.403 |
FARS2 | RPS15 | ENSP00000316335 | ENSP00000466010 | Phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins; Belongs to the class-II aminoacyl-tRNA synthetase family. | Ribosomal protein S15. | 0.554 |
FARS2 | RPS3 | ENSP00000316335 | ENSP00000278572 | Phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins; Belongs to the class-II aminoacyl-tRNA synthetase family. | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro- 8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] | 0.595 |
FARS2 | YARS1 | ENSP00000316335 | ENSP00000362576 | Phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins; Belongs to the class-II aminoacyl-tRNA synthetase family. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.920 |
FARSA | FARS2 | ENSP00000320309 | ENSP00000316335 | phenylalanyl-tRNA synthetase subunit alpha. | Phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.958 |
FARSA | LRRC47 | ENSP00000320309 | ENSP00000367498 | phenylalanyl-tRNA synthetase subunit alpha. | Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47. | 0.969 |
FARSA | RPS11 | ENSP00000320309 | ENSP00000270625 | phenylalanyl-tRNA synthetase subunit alpha. | Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. | 0.446 |
FARSA | RPS15 | ENSP00000320309 | ENSP00000466010 | phenylalanyl-tRNA synthetase subunit alpha. | Ribosomal protein S15. | 0.533 |
FARSA | RPS3 | ENSP00000320309 | ENSP00000278572 | phenylalanyl-tRNA synthetase subunit alpha. | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro- 8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] | 0.527 |
FARSA | YARS1 | ENSP00000320309 | ENSP00000362576 | phenylalanyl-tRNA synthetase subunit alpha. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.854 |
FDXACB1 | LRRC47 | ENSP00000260257 | ENSP00000367498 | Ferredoxin-fold anticodon-binding domain-containing protein 1; Ferredoxin-fold anticodon binding domain containing 1. | Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47. | 0.936 |
FDXACB1 | RPS15 | ENSP00000260257 | ENSP00000466010 | Ferredoxin-fold anticodon-binding domain-containing protein 1; Ferredoxin-fold anticodon binding domain containing 1. | Ribosomal protein S15. | 0.514 |